Journal ArticleDOI
Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord.
David J. Cutler,Richard Morris,Vimal Sheridhar,Trevor A. Wattam,Stephen Dudley Holmes,Sara Patel,Jonathan R.S. Arch,Shelagh Wilson,Robin E. Buckingham,Martyn L. Evans,Ron A. Leslie,Gareth Williams +11 more
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TLDR
Orexin cells are strategically sited to contribute to feeding regulation, but their widespread projections suggest that orexins have other physiological roles.About:
This article is published in Peptides.The article was published on 1999-12-01. It has received 215 citations till now. The article focuses on the topics: Orexin-A & Orexin.read more
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Journal ArticleDOI
Overlapping distributions of orexin/hypocretin‐ and dopamine‐β‐hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress
TL;DR: Investigation of overlap between dopamine‐β‐hydroxylase (DβH) ‐immunopositive projections and the projections of hypothalamic neurons containing the arousal‐ and feeding‐related peptide, orexin/hypocretin (HCRT), in rat brain found the projections jointly target several forebrain regions and brainstem monoaminergic nuclei involved in regulating core motivational processes.
Journal ArticleDOI
Functions of the orexinergic/hypocretinergic system
TL;DR: The present review focuses on the physiological properties of the cells that secrete or respond to orexins, which appear to be controlled by feeding- and sleep-related signals via a variety of neurotransmitters/hormones from the brain and other tissues.
Journal ArticleDOI
Projections of the paraventricular and paratenial nuclei of the dorsal midline thalamus in the rat.
TL;DR: PV/PT receive a vast array of afferents from the brainstem, hypothalamus, and limbic forebrain, related to arousal and attentive states of the animal, and would appear to channel that information to structures of the limbicForebrain in the selection of appropriate responses to changing environmental conditions.
Journal ArticleDOI
Differential modulation of nociceptive dural input to [hypocretin] orexin A and B receptor activation in the posterior hypothalamic area.
TL;DR: The results support the role of the PH in the nociceptive processing of meningeal input as orexinergic mechanisms in the PH may provide a link for endocrine and autonomic changes as well as nocICEptive phenomena seen in primary headache disorders.
Journal ArticleDOI
Hypothalamic control of energy balance: different peptides, different functions
TL;DR: Nine peptides in the hypothalamus that have emerged as key players in the process of energy homeostasis are summarized in an attempt to formulate a clear statement on the underlying function of each of these peptides and also on how they work together to create and maintain energyHomeostasis.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
Takeshi Sakurai,Akira Amemiya,Makoto Ishii,Ichiyo Matsuzaki,Richard M. Chemelli,Hirokazu Tanaka,S. Clay Williams,James A. Richardson,Gerald P. Kozlowski,Shelagh Wilson,Jonathan R.S. Arch,Robin E. Buckingham,Andrea C. Haynes,Steven A. Carr,Roland S. Annan,Dean E. McNulty,Wu Schyong Liu,Jonathan A. Terrett,Nabil Elshourbagy,Derk J. Bergsma,Masashi Yanagisawa +20 more
TL;DR: Two novel neuropeptides are identified, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors in the hypothalamus of rats.
Journal ArticleDOI
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
L de Lecea,Thomas S. Kilduff,Christelle Peyron,Xiao-Bing Gao,Pamela E. Foye,Patria E. Danielson,C. Fukuhara,Elena Battenberg,Vigdis T. Gautvik,Frederick S. Bartlett,Wayne N. Frankel,A. N. van den Pol,Floyd E. Bloom,Kaare M. Gautvik,J G Sutcliffe +14 more
TL;DR: A hypothalamus-specific mRNA is described that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin, suggesting that the hypocretins function within the CNS as neurotransmitters.
Journal ArticleDOI
Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
Christelle Peyron,Devin K. Tighe,Anthony N. van den Pol,Anthony N. van den Pol,Luis de Lecea,H. Craig Heller,J. Gregor Sutcliffe,Thomas S. Kilduff +7 more
TL;DR: The results of this immunohistochemical study suggest that hypocretins are likely to have a role in physiological functions in addition to food intake such as regulation of blood pressure, the neuroendocrine system, body temperature, and the sleep–waking cycle.
Related Papers (5)
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
Takeshi Sakurai,Akira Amemiya,Makoto Ishii,Ichiyo Matsuzaki,Richard M. Chemelli,Hirokazu Tanaka,S. Clay Williams,James A. Richardson,Gerald P. Kozlowski,Shelagh Wilson,Jonathan R.S. Arch,Robin E. Buckingham,Andrea C. Haynes,Steven A. Carr,Roland S. Annan,Dean E. McNulty,Wu Schyong Liu,Jonathan A. Terrett,Nabil Elshourbagy,Derk J. Bergsma,Masashi Yanagisawa +20 more