Differential Effects of Processing Time and Duration of Collagenase Digestion on Human and Murine Fat Grafts.
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TLDR
Human and murine adipocytes and human interstitial cells appear resistant to deleterious effects of increasing time following harvest, however, murine interstitial Cells are sensitive to increased time and prolonged collagenase digestion.Abstract:
Background:Autologous fat graft retention is unpredictable, and mechanisms of optimization are poorly understood. Attempts at improving retention use collagenase experimentally and clinically to isolate the stromal vascular fraction to “enhance” fat grafts. However, no standardized duration for collread more
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References
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M. T. Audrey Nguyen,Svetlana Favelyukis,Anh-Khoi Nguyen,Donna Reichart,Peter A. Scott,Alan Jenn,Ru Liu-Bryan,Christopher K. Glass,Jaap G. Neels,Jerrold M. Olefsky +9 more
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Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells
Kotaro Yoshimura,Katsujiro Sato,Noriyuki Aoi,Masakazu Kurita,Toshitsugu Hirohi,Kiyonori Harii +5 more
TL;DR: The preliminary results suggest that CAL is effective and safe for soft tissue augmentation and superior to conventional lipoinjection.
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Chemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte Metabolism
Kerry B. Goralski,Tanya C. McCarthy,Elyisha A. Hanniman,Brian A. Zabel,Brian A. Zabel,Eugene C. Butcher,Eugene C. Butcher,Sebastian D. Parlee,Shanmugam Muruganandan,Christopher J. Sinal +9 more
TL;DR: It is concluded that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism and has a role in adaptive and innate immunity.