Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
Marco Scarel,Silvia Marchesan +1 more
TLDR
Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts as discussed by the authors.Abstract:
Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts. They have attracted great interest in a variety of fields spanning from functional materials to drug discovery. This concise review will analyze the latest advancements in their synthesis, self-assembly into gels, and their more innovative applications.read more
Citations
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Cyclic Dipeptides: The Biological and Structural Landscape with Special Focus on the Anti-Cancer Proline-Based Scaffold
Joanna Bojarska,Adam Mieczkowski,Zyta M. Ziora,Mariusz Skwarczynski,Istvan Toth,Ahmed O. Shalash,Keykavous Parang,Shaima Ahmed El-Mowafi,Eman H M Mohammed,Sherif M. Elnagdy,Maha AlKhazindar,Wojciech M. Wolf +11 more
TL;DR: In this article, the authors present an updated review on the biological and structural profile of cyclic dipeptides, with a particular emphasis on those with anticancer properties, since cancers are the main cause of death all over the world.
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Bacterial Lipodepsipeptides and Some of Their Derivatives and Cyclic Dipeptides as Potential Agents for Biocontrol of Pathogenic Bacteria and Fungi of Agrarian Plants
TL;DR: Among the lipodepsipeptides and cyclic dipeptides assayed, tolaasin d and cyclo(l-Pro-l-Tyr) (also named maculosin-1) appeared to be the most toxic compounds.
Journal ArticleDOI
Short Peptide-Based Smart Thixotropic Hydrogels
TL;DR: This review will discuss the rational design and self-assembly of peptide-based thixotropic hydrogels with some representative examples, followed by their biomedical applications.
Journal ArticleDOI
Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities
TL;DR: The structure and activity of prototype ETPs such as gliotoxin are showcased and the current knowledge on the biosynthesis routes of these exceptional natural products is discussed.
Journal ArticleDOI
Self-Assembled Peptide Nanostructures for ECM Biomimicry
TL;DR: This Review will analyze the last 5-year progress on the incorporation of bioactive motifs into self-assembling peptides to mimic functional proteins of the extracellular matrix and guide cell fate inside hydrogel scaffolds.
References
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2,5-Diketopiperazines: synthesis, reactions, medicinal chemistry, and bioactive natural products.
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TL;DR: In this article, the differences between printed electronics and inorganic materials are exploited via molecular-level control of functionality compared with inorganic electronics if they are to become commercially viable for flexible displays.
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Lihi Adler-Abramovich,Daniel Aronov,Peter Beker,Maya Yevnin,Shiri Stempler,Ludmila Buzhansky,Gil Rosenman,Ehud Gazit +7 more
TL;DR: This work demonstrates the self-assembly of large arrays of aromatic peptide nanotubes using vapour deposition methods and shows that the nanotube arrays can be used to develop high-surface-area electrodes for energy storage applications, highly hydrophobic self-cleaning surfaces and microfluidic chips.
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TL;DR: FT-IR spectroscopy indicated that a driving force for gelation was intermolecular hydrogen bonding between amides and that the phase transition from gel to liquid upon heating was brought about by the collapse of hydrogen bonding.
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Catalytic peptide assemblies
TL;DR: Different strategies used to rationally develop self-assembled peptide catalysts with natural and unnatural backbones as well as with metal-containing cofactors are discussed.