Journal ArticleDOI
Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo.
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TLDR
Two diphosphonates containing the P-C-P bond inhibit the crystallization of calcium phosphate in vitro and prevent aortic calcification of rats given large amounts of vitamin D3.Abstract:
Two diphosphonates containing the P-C-P bond, CH(3)C(OH)(PO(3)HNa)(2) and H(2)C(PO(3)HNa)(2), inhibit the crystallization of calcium phosphate in vitro and prevent aortic calcification of rats given large amounts of vitamin D(3). The diphosphonates therefore have effects similar to those described for compounds containing the P-O-P bond but are active when administered orally.read more
Citations
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Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy
TL;DR: Each bisphosphonates has a unique profile that may help to explain potential clinical differences among them, in terms of their speed and duration of action, and effects on fracture reduction.
Journal ArticleDOI
Bisphosphonates: Mechanisms of Action
TL;DR: A comparison study of the effects of calcification, bone resorption, and other effects on bone formation and noncalcified tissues in animals and humans using a model derived from animal toxicology and human adverse events.
Journal ArticleDOI
Bisphosphonates: mechanisms of action.
Gideon A. Rodan,Herbert Fleisch +1 more
TL;DR: This review will deal with the mechanisms of action of bisphosphonates and in vitro results, as well as results both in animals and humans, will be integrated in an attempt to deduce the current state of the art.
Journal ArticleDOI
Bisphosphonates: The first 40 years
TL;DR: The discovery and development of the bisphosphonates (BPs) as a major class of drugs for the treatment of bone diseases has been a fascinating story, and a paradigm of a successful journey from 'bench to bedside'.
Journal ArticleDOI
Bisphosphonates: from the laboratory to the clinic and back again.
R.G.G. Russell,Michael J. Rogers +1 more
TL;DR: The marked structure-activity relationships observed among more complex compounds indicate that the pharmacophore required for maximal activity not only depends upon the bisphosphonate moiety but also on key features, e.g., nitrogen substitution in alkyl or heterocyclic side chains.
References
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Journal ArticleDOI
Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis.
Journal ArticleDOI
Mechanisms of calcification: role of collagen, polyphosphates, and phosphatase.
Herbert Fleish,William F. Neuman +1 more
TL;DR: The nucleating properties of various collagens have been tested by determining quantitatively the minimum ion product, Ca times P, required to form calcium phosphate crystals.
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The inhibition of calcium hydroxypatite crystal growth by polyphosphonates and polyphosphates.
TL;DR: The stability of the polyphosphonates and their chemisorption on apatite suggest their use in medical and dental applications involving pathological calcium and phosphate metabolism.
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Mechanism of Calcification: Inhibitory Role of Pyrophosphate
Herbert Fleisch,Sylvia Bisaz +1 more
TL;DR: This work showed plasma to contain one or several substances highly inhibitory to apatite precipitation, and suggested this inhibitor to be a polyphosphate, but to the knowledge, no such compound has so far been demonstrated in plasma or in urine.