Journal ArticleDOI
Direct thrombin inhibitors.
P. Joshua O’Brien,Leila Mureebe +1 more
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TLDR
Thrombin is essential to coagulation, and makes for a very attractive target in medical intervention of pathologic thrombosis, and the nature of direct thrombin inhibitors is reviewed.Abstract:
Cardiovascular disease is a leading cause of death and pathologic coagulation plays an integral role in the development, propagation, and intervention of cardiovascular disease. The 2 classic anticoagulants, heparin and vitamin K antagonists, though having served humanity for nearly a century, are both inconvenient and nonspecific. Through both direct and indirect roles, thrombin is essential to coagulation, and makes for a very attractive target in medical intervention of pathologic thrombosis. This article will review the nature of direct thrombin inhibitors, current indications, and ongoing trials.read more
Citations
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Deborah J. Stearns-Kurosawa,Marcin F. Osuchowski,Catherine Valentine,Shinichiro Kurosawa,Daniel G. Remick +4 more
TL;DR: Biomarkers may be used to help diagnose patients with sepsis, and they may also help to identify patients who would benefit from immunomodulatory therapies.
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Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image-guided interventions.
Indravadan Patel,J. Davidson,Boris Nikolic,Gloria Salazar,Marc S. Schwartzberg,T. Gregory Walker,Wael A. Saad +6 more
TL;DR: From the Division of Vascular and Interventional Radiological, Jefferson Radiology, Hartford Hospital, 85 Seymour St, Ste 200, Hartford, CT 06106, Received November 18, 2008; accepted November 24, 2008.
Journal ArticleDOI
Society of Interventional Radiology Consensus Guidelines for the Periprocedural Management of Thrombotic and Bleeding Risk in Patients Undergoing Percutaneous Image-Guided Interventions-Part II: Recommendations: Endorsed by the Canadian Association for Interventional Radiology and the Cardiovascular and Interventional Radiological Society of Europe.
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Proteases as therapeutics.
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Heparin-Induced Thrombocytopenia: A Comprehensive Clinical Review
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References
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Journal ArticleDOI
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