Journal ArticleDOI
Distribution of D-amino acid oxidase (DAO) activity in the medulla and thoracic spinal cord of the rat: implications for a role for D-serine in autonomic function.
Ranjna Kapoor,Vimal Kapoor +1 more
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TLDR
DAO activity was noticeably low or absent in the nucleus of the solitary tract, ventrolateral medulla and intramediolateral cell column of the spinal cord, indicative of a neuromodulatory role for endogenous D-serine (at the NMDA-glycine site) in in the central control of blood pressure.About:
This article is published in Brain Research.The article was published on 1997-10-17. It has received 24 citations till now. The article focuses on the topics: Solitary tract & Spinal cord.read more
Citations
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Journal ArticleDOI
Chemistry, nutrition, and microbiology of D-amino acids.
TL;DR: This multidiscipline-oriented overview surveys the present knowledge of the chemistry, nutrition, safety, microbiology, and pharmacology of D-amino acids.
Journal ArticleDOI
Physiological functions of D-amino acid oxidases: from yeast to humans
TL;DR: Current research is attempting to delineate the regulation of DAAO functions in the contest of complex biochemical and physiological networks.
Journal ArticleDOI
Metabolism of the neuromodulator d -serine
TL;DR: An overview of the current knowledge of the metabolism of d-serine in human brain at the molecular and cellular levels, with a specific emphasis on the brain localization and regulatory pathways of d -serine, serine racemase, and d-amino acid oxidase is presented.
Journal ArticleDOI
Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1).
TL;DR: Investigation of gene expression and biochemical activities of enzymes d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 revealed elevated cerebellar KAT-1 and DAAO activities in post-mortem brain samples from schizophrenic versus normal individuals.
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A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats.
TL;DR: Spinal DAO mediates both induction and maintenance of formalin-induced tonic pain and further validate spinal DAO as a novel and efficacious target molecule for the treatment of chronic pain.
References
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Journal ArticleDOI
Glycine potentiates the NMDA response in cultured mouse brain neurons
J. W. Johnson,P Ascher +1 more
TL;DR: G glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor, and can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
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D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.
TL;DR: D-Serine appears to be the endogenous ligand for the glycine site of NMDA receptors, suggesting a mechanism by which astrocyte-derived D-serine could modulate neurotransmission.
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The glycine site of the NMDA receptor — five years on
John A. Kemp,Paul D. Leeson +1 more
TL;DR: The glycine site on the NMDA receptor complex has generated an enormous amount of interest since it was first described five years ago and studies with prototype antagonists, and low-efficacy partial agonists that penetrate the brain, show that these compounds possess anticonvulsant and neuroprotective properties but lack some of the side-effects of other types of NMDA antagonists.
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The presence of free D‐serine in rat brain
Atsushi Hashimoto,Toru Nishikawa,Tohiski Hayashi,Noriko Fujii,Kaoru Harada,Takae Oka,Kiyohisa Takahashi +6 more
TL;DR: These data provide the first evidence that substantial quantities of free D‐serine are present in mammalian brain tissues, and a peak X, which exhibited the same retention time as the N,O‐pentafluoropropionyl isopropyl derivative of authentic D‐Serine, was detected in the brain extracts.
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d-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors
TL;DR: Compared the immunohistochemical localizations of d-serine, glycine, and NMDA receptors in rat brain, d-Serine seems to be the endogenous ligand of glycine sites in the telencephalon and developing cerebellum, whereas glycine predominates in the adult cere Bellum, olfactory bulb, and hindbrain.