Journal ArticleDOI
Divergent effects of serotonin on coronary-artery dimensions and blood flow in patients with coronary atherosclerosis and control patients.
Paolo Golino,Federico Piscione,James T. Willerson,Maurizio Cappelli-Bigazzi,Amelia Focaccio,Bruno Villari,Ciro Indolfi,E Russolillo,Mario Condorelli,Massimo Chiariello +9 more
TLDR
Serotonin has a vasodilating effect on normal human coronary arteries; when the endothelium is damaged, as in coronary artery disease, serotonin has a direct, unopposed vasoconstricting effect; and platelet-derived factors such as serotonin may have a role in certain acute coronary ischemic syndromes.Abstract:
Background. Studies in animals have shown that serotonin constricts coronary arteries if the endothelium is damaged, but in vitro studies have revealed a vasodilating effect on isolated coronary segments with an intact endothelium. To investigate the effect of serotonin in humans, we studied coronary-artery cross-sectional area and blood flow before and after the infusion of serotonin in seven patients with angiographically normal coronary arteries and in seven with coronary artery disease. Methods. We measured the cross-sectional area of the coronary artery by quantitative angiography and coronary blood flow with an intracoronary Doppler catheter. Measurements were obtained at base line and during intracoronary infusions of serotonin (0.1, 1, and 10 μg per kilogram of body weight per minute, for two minutes). We repeated the measurements after an infusion of ketanserin, an antagonist of serotonin receptors that is thought to block the effect of serotonin on receptors in the arterial wall but not...read more
Citations
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Endothelial Dysfunction A Marker of Atherosclerotic Risk
TL;DR: Given its reversibility and granted the availability of a diagnostic tool to identify patients at risk and to control the efficacy of therapy in clinical practice, endothelial dysfunction may be an attractive primary target in the effort to optimize individualized therapeutic strategies to reduce cardiovascular morbidity and mortality.
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Endothelial Function Cardiac Events
Amir Lerman,Andreas M. Zeiher +1 more
TL;DR: The present review is focused on the potential underlying mechanism by which endothelial dysfunction may contribute to cardiovascular events, and the localization and distribution of the endothelial cell layer.
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Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine
TL;DR: It is suggested that hypercholesterolaemia impairs endothelium-dependent dilatation of the coronary microcirculation and that this impairment can be restored by short-term administration of L-arginine.
Journal ArticleDOI
Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure
Georg Kojda,David G. Harrison +1 more
TL;DR: There is a growing body of evidence suggesting that numerous pathological conditions are associated with increased vascular production of reactive oxygen species, and this form of vascular oxidant stress and particularly interactions between NO and oxygen-derived radicals represent a common pathological mechanism present in many so-called risk factors for atherosclerosis.
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Regulation of the Cerebral Circulation: Role of Endothelium and Potassium Channels
Frank M. Faraci,D. D. Heistad +1 more
TL;DR: This review focuses on some physiological mechanisms of cerebral vasodilatation and alteration of these mechanisms by disease states.
References
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Journal Article
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