Journal ArticleDOI
Diversity-oriented synthesis as a tool to expand the chemical space of DNA-encoded libraries.
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TLDR
In this paper, a review of DNA-compatible complexity-generating reactions that can be applied for the generation of DNAencoded DOS libraries, including: (i) multicomponent reactions; (ii) C-H/C-X functionalization; (iii) tandem approaches; (iv) cycloadditions; (v) reactions introducing privileged elements.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2021-05-15. It has received 12 citations till now. The article focuses on the topics: Chemical space.read more
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Strategies for developing DNA-encoded libraries beyond binding assays
Yiran Huang,Yizhou Li,Xiaoyu Li +2 more
TL;DR: The recent progress in using DNA-encoded chemical libraries to interrogate complex biological targets and their potential to identify structures that elicit function or possess other useful properties are discussed.
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Visible Light-Promoted Divergent Benzoheterocyclization from Aldehydes for DNA-Encoded Chemical Libraries.
TL;DR: A visible light-promoted divergent synthesis of on-DNA benzoheterocycles from aldehydes is presented, demonstrating the feasibility of this approach in DNA-encoded chemical library construction.
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Sequential DNA-Encoded Building Block Fusion for the Construction of Polysubstituted Pyrazoline Core Libraries.
TL;DR: A sequential DNA-encoded synthesis strategy for polysubstituted pyrazoline heterocycles, which fuses a broad panel of aldehydes, aryl amines, and alkenes as building blocks, was presented in this paper.
Journal ArticleDOI
Converting Double-Stranded DNA-Encoded Libraries (DELs) to Single-Stranded Libraries for More Versatile Selections
TL;DR: It is shown that dsD ELs could be efficiently converted to ssDELs and used for affinity-based selections either with purified proteins or on live cells.
Journal ArticleDOI
Recent advances in DNA-encoded dynamic libraries
Bingbing Shi,Yu Zhou,Xiaoyu Li +2 more
TL;DR: The DNA-encoded dynamic combinatorial libraries (DCLs) as mentioned in this paper have been widely adopted in the pharmaceutical industry and a number of clinical drug candidates have been identified from DEL selections.
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