Journal ArticleDOI
Dizocilpine antagonizes the effect of chronic imipramine on learned helplessness in rats
Domenico Meloni,Carla Gambarana,Maria Graziella De Montis,Paolo Dal Pra,Italo Taddei,Alessandro Tagliamonte +5 more
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TLDR
It is shown that dizocilpine completely antagonized the capacity of IMI to prevent the development of the learned helplessness behavior in rats, suggesting that the blockade of NMDA receptors also antagonizes the antidepressant effect of I MI.Abstract:
Dizocilpine coadministered with imipramine (IMI) through an SC-implanted osmotic minipump completely prevents the occurence of behavioral supersensitivity to quinpirole, as well as the decrease of dopamine D1 and β-adrenergic receptor function. The present report shows that, in the same experimental conditions, dizocilpine completely antagonized the capacity of IMI to prevent the development of the learned helplessness behavior in rats. Thus suggesting that the blockade of NMDA receptors also antagonizes the antidepressant effect of IMI. Interestingly, rats acutely treated with dizocilpine 30 min before the inescapable shock session behaved similarly to naive animals during the escape test session.read more
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Antidepressant effects of ketamine in depressed patients
Robert M. Berman,Angela Cappiello,Amit Anand,Amit Anand,Dan A. Oren,Dan A. Oren,George R. Heninger,Dennis S. Charney,Dennis S. Charney,John H. Krystal,John H. Krystal +10 more
TL;DR: A first placebo-controlled, double-blinded trial to assess the treatment effects of a single dose of an N-methyl-D-aspartate (NMDA) receptor antagonist in patients with depression suggests a potential role for NMDA receptor-modulating drugs in the treatment of depression.
Journal ArticleDOI
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression
Carlos A. Zarate,Jaskaran Singh,Paul J. Carlson,Nancy E. Brutsche,Rezvan Ameli,David A. Luckenbaugh,Dennis S. Charney,Husseini K. Manji +7 more
TL;DR: Robust and rapid antidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist; onset occurred within 2 hours postinfusion and continued to remain significant for 1 week.
Journal ArticleDOI
A Randomized Add-on Trial of an N-methyl-d-aspartate Antagonist in Treatment-Resistant Bipolar Depression
Nancy Diazgranados,Lobna Ibrahim,Nancy E. Brutsche,Andrew B. Newberg,Phillip Kronstein,Sami Khalife,William A. Kammerer,Zenaide M.N. Quezado,David A. Luckenbaugh,Giacomo Salvadore,Rodrigo Machado-Vieira,Husseini K. Manji,Carlos A. Zarate +12 more
TL;DR: In patients with treatment-resistant bipolar depression, robust and rapid antidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate-receptor antagonist.
Journal ArticleDOI
Glutamate as a therapeutic target in psychiatric disorders.
TL;DR: Metabotropic modulators are currently under preclinical development for neuropsychiatric conditions, including schizophrenia, depression and anxiety disorders, and other conditions for which glutamate modulators may prove effective include stroke, epilepsy, Alzheimer disease and PTSD.
Journal ArticleDOI
An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.
Sheldon H. Preskorn,Bryan Baker,Sheela Kolluri,Frank S. Menniti,Michael Krams,Jaren W. Landen +5 more
TL;DR: CP-101,606 was safe, generally well tolerated, and capable of producing an antidepressant response without also producing a dissociative reaction, andagonism of the NR2B subtype of the N-methyl-D-aspartate receptor may be a fruitful target for the development of a new antidepressant with more robust effects and a faster onset.
References
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Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801.
Keith A. Trujillo,Huda Akil +1 more
TL;DR: The present studies suggest that NMDA receptors may be important in the development of opiate tolerance and dependence.
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Journal ArticleDOI
Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
Ramon Trullas,Phil Skolnick +1 more
TL;DR: The hypothesis that pathways subserved by the NMDA subtype of glutamate receptors are involved in the pathophysiology of affective disorders may have heuristic value and that substances capable of reducing neurotransmission at theNMDA receptor complex may represent a new class of antidepressants is investigated.
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Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala.
TL;DR: The results show that infusion of the NMDA antagonist D,L-2- amino-5-phosphonovaleric acid (AP5) into the amygdala, a limbic structure known to be important for fear conditioning, dose-dependently blocked extinction of conditioned fear and suggest that an NMDA-dependent process might underlie the extinction of Conditioned fear.
Journal ArticleDOI
Blockade of "reverse tolerance" to cocaine and amphetamine by MK-801.
TL;DR: The data suggest that the glutamate system participates in the mechanism of "reverse tolerance" to the dopaminergic effects of cocaine and amphetamine, as well as to the convulsant effect of cocaine.
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Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
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