Journal ArticleDOI
DNA binding and nuclease activity of copper(II) complexes of tridentate ligands
Pankaj Kumar,Basudeb Baidya,Sumit Kumar Chaturvedi,Rizwan Hasan Khan,Debasis Manna,Biplab Mondal +5 more
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TLDR
Two copper(II) complexes with L 1 and L 2 ligands, respectively, have been synthesized and characterized and the interaction of both the complexes with DNA has been studied to explore their poten-tial biological activity.About:
This article is published in Inorganica Chimica Acta.The article was published on 2011-10-01. It has received 57 citations till now. The article focuses on the topics: DNA & Binding constant.read more
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Elucidating the interaction of limonene with bovine serum albumin: a multi-technique approach
Sumit Kumar Chaturvedi,Ejaz Ahmad,Javed Masood Khan,Parvez Alam,Mohd Ishtikhar,Rizwan Hasan Khan +5 more
TL;DR: The present study will be helpful in understanding the binding mechanism of limonene and associated stability and conformational changes.
Journal ArticleDOI
Biophysical and molecular docking insight into the interaction of cytosine β-D Arabinofuranoside with Human serum albumin
Parvez Alam,Sumit Kumar Chaturvedi,Tamanna Anwar,Mohammad Khursheed Siddiqi,Mohd Rehan Ajmal,Gamal Badr,Mohamed H. Mahmoud,Rizwan Hasan Khan +7 more
TL;DR: This study will be helpful to understand the binding mechanism of cytosine β-D arabinofuranoside with HSA and associated alterations and help understand the topology of protein in absence and presence of drug.
Journal ArticleDOI
DNA binding, nuclease activity and cytotoxicity studies of Cu(II) complexes of tridentate ligands.
TL;DR: In vitro cytotoxicity assay of theCu(II) complexes demonstrate that the complexes have low toxicity for different cancer cell lines and IC(50) values were between 37 and 156 μM.
Journal ArticleDOI
Gadolinium(III) and dysprosium(III) complexes with a Schiff base bis(N-salicylidene)-3-oxapentane-1,5-diamine: synthesis, characterization, antioxidation, and DNA-binding studies
TL;DR: A pentadentate Schiff base bis(N-salicylidene)-3-oxapentane-1,5-diamine (H2L) and its lanthanide(III) complexes, [GdL(NO3)(DMF)(H2O)] (1) and [Dy2L2( NO3)2]·2H 2O (2), have been synthesized and characterized by physical, chemical, and spectroscopic methods as mentioned in this paper.
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Study on synthesis, crystal structure, antioxidant and DNA-binding of mono-, di- and poly-nuclear lanthanides complexes with bis(N-salicylidene)-3-oxapentane-1,5-diamine.
TL;DR: The antioxidant activity experiments show that these compounds also exhibit good antioxidant activities against OH· and O2(-·) in vitro studies and the DNA-binding properties have been investigated by electronic absorption, fluorescence, and viscosity measurements, suggesting that the ligand and complexes bind to DNA via groove modes.
References
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ORTEP-3 for Windows - a version of ORTEP-III with a Graphical User Interface (GUI)
TL;DR: L Lists of software presented and~or reviewed in the Journal of Applied Crystallography are available on the World Wide Web at the above address, together with information about the availability of the software where this is known.
Book
Principles of Biochemistry
TL;DR: The third edition, coming ten years after the first, emphasizes both the flowering of biochemical research and the prodigious effort by busy teachers and scientists to keep up to date this popular text and reference.
Journal ArticleDOI
Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.
TL;DR: The results indicate that the binding of any non-interacting ligand covering more than one lattice residue results in non- linear (convex downward) Scatchard plots, and the introduction of positive ligand-ligand co-operativity antagonizes this non-linearity, and eventually leads to plots of the opposite curvature.
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A fluorescent complex between ethidium bromide and nucleic acids. Physical-chemical characterization.
J.-B. Lepecq,Claude Paoletti +1 more
TL;DR: Evidence is presented that formation of this complex (complex I) is specific for base-paired regions either in DNA, RNA or RNA: DNA hybrids, and that the basis of this specificity is intercalation of the dye between base pairs.