Journal ArticleDOI
Docosahexaenoic acid inhibits IL-6 expression via PPARγ-mediated expression of catalase in cerulein-stimulated pancreatic acinar cells.
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TLDR
DHA induces PPARγ activation and catalase expression, which inhibits ROS-mediated activation of JAK2/STAT3 and IL-6 expression in cerulein-stimulated pancreatic acinar cells.About:
This article is published in The International Journal of Biochemistry & Cell Biology.The article was published on 2017-07-01. It has received 33 citations till now. The article focuses on the topics: Peroxisome proliferator-activated receptor & Catalase.read more
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Journal ArticleDOI
Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors
TL;DR: The peroxisome proliferator-activated receptor (PPAR) family includes three transcription factors: PPARα, PPARβ/δ, and PPARγ which are nuclear receptors activated by oxidised and nitrated fatty acid derivatives as well as by cyclopentenone prostaglandins during the inflammatory response.
Journal ArticleDOI
miR-148a suppresses autophagy by down-regulation of IL-6/STAT3 signaling in cerulein-induced acute pancreatitis.
Bin Miao,Wen-jie Qi,Shu-wen Zhang,Hong Wang,Chao Wang,Lan Hu,Guang-wei Huang,Shi-rong Li,He Wang +8 more
TL;DR: Findings indicate that miR-148a suppresses autophagy via regulating IL-6/STAT3 signaling in cerulein-induced AP in vitro and in-vivo.
Journal ArticleDOI
A Mini-Review on the Effect of Docosahexaenoic Acid (DHA) on Cerulein-Induced and Hypertriglyceridemic Acute Pancreatitis
Yoo Kyung Jeong,Hyeyoung Kim +1 more
TL;DR: DHA supplementation may be beneficial for preventing or inhibiting acute pancreatitis development, and the relation of high concentration of DHA to hyperlipidemic acute Pancreasitis has been included.
Journal ArticleDOI
Antioxidant Activity of Docosahexaenoic Acid (DHA) and Its Regulatory Roles in Mitochondria.
Guiling Li,Yuanyuan Li,Baoping Xiao,Dongyue Cui,Yanqi Lin,Jun Zeng,Jian Li,Min-Jie Cao,Jingwen Liu +8 more
TL;DR: In this paper, the effect of DHA's effect on cellular antioxidant capacity and mitochondrial functions was examined in HepG2 cells, and the results showed that 100 μM DHA decreased cellular and mitochondrial ROS levels to 75.2 ± 9.4% (P < 0.05) and 55.1 ± 1.4%, respectively.
Journal ArticleDOI
Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism
Rishabh Khera,Sidharth Mehan,Sonali Bhalla,Sumit Kumar,Abdulrahman Alshammari,Metab Alharbi,Satya S. Sadhu +6 more
TL;DR: Guggulsterone was observed to improve autism-like behavioural impairments in autistic rats treated with PPA, and restored neurochemical deficits in a dose-dependent manner.
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Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
TL;DR: A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).
Journal ArticleDOI
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
TL;DR: Inhibition of cytokine production may help to explain the incremental therapeutic benefit of NSAIDs observed in the treatment of rheumatoid arthritis at plasma drug concentrations substantially higher than are required to inhibit prostaglandin G/H synthase (cyclooxygenase).
Journal ArticleDOI
The Mechanisms of Action of PPARs
Joel P. Berger,David E. Moller +1 more
TL;DR: The current state of knowledge regarding the molecular mechanisms of PPAR action and the involvement of the PPARs in the etiology and treatment of several chronic diseases is presented.
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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
Jin Jiang,Gary Struhl +1 more
TL;DR: A new gene is described, slimb (for supernumerary limbs), which negatively regulates both of these signal transduction pathways and encodes a conserved F-box/WD40-repeat protein related to Cdc4p, a protein in budding yeast that targets cell-cycle regulators for degradation by the ubiquitin/proteasome pathway.
Journal ArticleDOI
Peroxisome proliferator-activated receptors in inflammation control.
TL;DR: Findings indicate a modulatory role for PPARs in inflammation with potential therapeutical applications in chronic inflammatory diseases.