Open AccessJournal Article
Dose-dependent effect of copper chloride on male reproductive function in immature rats
TLDR
It is suggested that copper has got a dose-dependent effect on testicular steroidogenic enzyme activity and stimulation of testicular spermatogenesis and serum testosterone and LH level in maturing male rats.Abstract:
Background: Copper is essential as a trace element for metabolic processes. Exposure to copper in industries develops toxicity among the workers. Previous findings on adverse effects of copper on male reproductive function in adult albino rats led to investigate the effects of this metal on reproductive function of maturing male rats in the present experiment. Methodology: To study these effects, immature (30 to 35 days old) Wistar strain albino rats weighing about 50-60 g were treated intraperitoneally with copper chloride at doses of 1000, 2000 and 3000 µg/kg body weight/day for 26 days. Result: Significant fall in accessory sex organ weight and inhibition of testicular 17β-hydroxysteroid dehydrogenase activity along with degeneration of testicular growing spermatogenic cells and reduction in serum testosterone, FSH and LH level were observed at the doses of 2000 and 3000µg/kg/day. On the other hand, at the dose of 1000 µg/kg/day significant increase in testicular steroidogenic enzyme activity and stimulation of testicular spermatogenesis along with rise in serum testosterone and LH level were observed, though no significant change was observed in serum FSH level. This suggests that copper has got a dose-dependent effect on testicular steroidogenesis and spermatogenesis and serum testosterone and LH level in maturing male rats.read more
Citations
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Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum
John D. Meeker,M.G. Rossano,Bridget Protas,Vasantha Padmanahban,Michael P. Diamond,Elizabeth E. Puscheck,Douglas C. Daly,Nigel Paneth,Julia J. Wirth +8 more
TL;DR: Although reductions in T and reproductive toxicity after molybdenum exposure have been previously demonstrated in animal studies, more research is needed to determine whether moly bdenum poses a risk to human reproductive health.
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Antioxidant effect of vitamin E treatment on some heavy metals-induced renal and testicular injuries in male mice
TL;DR: Administration of vitamin E protects against heavy metals-induced renal and testicular oxidative stress and injuries in mice treated with these heavy metals, as evidenced by appearance of normal histological structures, insignificant changes in the values of plasma creatinine, urea and uric acid, and the levels of kidney GSH and SOD.
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Environmental and occupational exposure of metals and their role in male reproductive functions.
TL;DR: This review summarizes the effects of more than 20 metals that, research has indicated, may influence male reproductive health and suggests a need for further research in those chemicals that are reactive and capable of covalent interactions in biological systems.
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The effects of diazinon on testosterone, FSH and LH levels and testicular tissue in mice.
TL;DR: DZN is a toxicant for mammals’ spermatogenic cells during the early sperMatogenesis and application of DZN should be limited to a designed program.
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Comparative toxicity and biodistribution assessments in rats following subchronic oral exposure to copper nanoparticles and microparticles
In-Chul Lee,In-Chul Lee,Je-Won Ko,Sung-Hyeuk Park,Na-Rae Shin,In-Sik Shin,Changjong Moon,Je-Hein Kim,Hyoung-Chin Kim,Jong-Choon Kim +9 more
TL;DR: Overall, the in vivo repeated dose toxicity study of Cu NPs and Cu MPs demonstrated that large surface area and high solubility in physiological milieus could directly influence the toxicological responses and biodistribution of Cu particles when administered orally.
References
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The preparation of 131i-labelled human growth hormone of high specific radioactivity
TL;DR: The loss of immunological reactivity at high specific radioactivities or at high levels of chemical substitution with STAI/sup 127/!iodine is demonstrated.
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Definition of the Stages of the Cycle of the Seminiferous Epithelium in the Rat
C. P. Leblond,Yves Clermont +1 more
TL;DR: In the present work, the cellular associations were defined by the stage of development of the spermatids, which themselves were characterized by their staining reaction to the “periodic acid-Schiff” technique (hereafter referred to as PAFSA).
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Hormonal control of mammalian spermatogenesis
TL;DR: Results from the studies indicate that changes in the metabolism of proteins lipids and carbohydrates take place in the testes under the control of hormones, but it may be that the observed biochemical changes are a reflection of the changes in cellular composition of testicular tissue rather than the result of metabolic changes within a specific cell type in response to the effect of a hormone.
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Purification of a 17β-Hydroxysteroid Dehydrogenase of Human Placenta and Studies on Its Transhydrogenase Function
TL;DR: Methods for the extensive purification of a soluble 17@-hydroxysteroid dehydrogenasel of human placenta are described, which appears to be responsible for the entire 17/3estradiol-mediated transfer of hydrogen between pyridine nucleotides in soluble extracts of this tissue.