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Open AccessJournal ArticleDOI

Dose–response relationships of psilocybin-induced subjective experiences in humans:

TLDR
In this article, the quality of the psilocybin-induced experience might mediate beneficial health outcategories: Psilocybe mushrooms, magic mushrooms, hallucinogenic drugs, psychoactive components in magic mushrooms.
Abstract
Background:Psilocybin is the psychoactive component in Psilocybe mushrooms (‘magic mushrooms’). Whether and how the quality of the psilocybin-induced experience might mediate beneficial health outc...

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Citations
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Classic Psychedelic Drugs: Update on Biological Mechanisms

TL;DR: In this paper , the effects of psychedelics in the treatment of psychiatric disorders have been investigated and it has been shown that changes in self-experience, emotional processing, and social cognition may contribute to the potential therapeutic effects of these substances.
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Psilocybin-Induced Mystical-Type Experiences are Related to Persisting Positive Effects: A Quantitative and Qualitative Report

TL;DR: In this article , the authors provide qualitative descriptions of the "complete mystical experience" induced by orally administered psilocybin in healthy volunteers, revealing themes such as a sense of connection with the universe, familial love, and the experience of profound beauty.
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Safety pharmacology of acute LSD administration in healthy subjects.

TL;DR: In this paper, the authors report safety pharmacology data from a large pooled study sample on acute effects of LSD in healthy subjects, which includes a total of 83 healthy subjects and 131 single-dose administrations of LSD.
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Dosing Psychedelics and MDMA.

TL;DR: In this article, the authors discuss different aspects of psychedelic dosing, including pharmaceutical aspects, definitions and characteristics of different doses, including microdoses, aspects of personalized dosing and non-pharmacological factors, that can influence the response to psychedelics.
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Altered states phenomena induced by visual flicker light stimulation.

TL;DR: The data demonstrate that flicker light stimulation is capable of inducing visual effects with an intensity rated to be similar in strength to effects induced by psychedelic substances and thereby support the investigation of potentially shared underlying neuronal mechanisms.
References
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Journal ArticleDOI

Quantifying heterogeneity in a meta‐analysis

TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
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Robust variance estimation in meta-regression with dependent effect size estimates.

TL;DR: This paper provides an estimator of the covariance matrix of meta-regression coefficients that is applicable when there are clusters of internally correlated estimates and demonstrates that the meta- Regression coefficients are consistent and asymptotically normally distributed and that the robust variance estimator is valid even when the covariates are random.
Journal ArticleDOI

Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance.

TL;DR: When administered under supportive conditions, psilocybin occasioned experiences similar to spontaneously occurring mystical experiences, and the ability to occasion such experiences prospectively will allow rigorous scientific investigations of their causes and consequences.
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Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial.

TL;DR: High-dose psilocybin produced large decreases in clinician- and self-rated measures of depressed mood and anxiety, along with increases in quality of life, life meaning, and optimism, and decreases in death anxiety.
Journal ArticleDOI

Basics of meta‐analysis: I2 is not an absolute measure of heterogeneity.

TL;DR: If you want to communicate the predicted range of effects, then you should simply report this range, which gives readers the information they think is being captured by I2 and does so in a way that is concise and unambiguous.
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What are the relationships between mushrooms and humans?

The paper explores the dose-response relationships of psilocybin-induced subjective experiences in humans.