Journal ArticleDOI
Early diagnosis of HIV infection in infants by detection of IgA HIV antibodies
Barbara J. Weiblen,R. Hoff,Francis K. Lee,Steven Nesheim,A.J. Nahmias,Ellen R. Cooper,J.S. Harris,Stephen I. Pelton,S.H. Landesman,H. Mendez,Kenneth McIntosh +10 more
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TLDR
The correlation of the serological results with clinical information on each child suggests that detection of IgA HIV antibodies is an effective method for early diagnosis of HIV-infected infants without signs of infection.About:
This article is published in The Lancet.The article was published on 1990-04-28. It has received 111 citations till now. The article focuses on the topics: Serology & Acquired immunodeficiency syndrome (AIDS).read more
Citations
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Journal ArticleDOI
Pathogenesis of human immunodeficiency virus infection.
TL;DR: The observations indicate the major challenge of preventing infection by HIV appears to involve infection with a relatively low-virulence strain that remains sensitive to the immune response, particularly to control by CD8+ cell antiviral activity.
Journal ArticleDOI
Prevalence of HIV infection in childbearing women in the United States. Surveillance using newborn blood samples.
Marta Gwinn,Marguerite Pappaioanou,J. Richard George,W. Harry Hannon,Shari C. Wasser,Martha A. Redus,Rodney Hoff,George F. Grady,Anne Willoughby,Antonia C. Novello,Lyle R. Petersen,Timothy J. Dondero,James Curran +12 more
TL;DR: A national, population-based survey was initiated in 1988 to measure the prevalence of human immunodeficiency virus (HIV) infection in women giving birth to infants in the United States and it is estimated that approximately 1800 newborns acquired HIV infection during one 12-month period.
Journal ArticleDOI
The use of viral culture and p24 antigen testing to diagnose human immunodeficiency virus infection in neonates
Marianne Burgard,Marie-Jeanne Mayaux,Stéphane Blanche,Agnès Ferroni,M.L. Guihard‐Moscato,Marie-Christine Allemon,Nicole Ciraru-Vigneron,Ghislaine Firtion,Corinne Floch,François Guillot,Eric Lachassine,Michèle Vial,Claude Griscelli,Christine Rouzioux +13 more
TL;DR: The fact that this usually sensitive technique fails to identify about half the ultimately infected neonates suggests that vertical transmission of HIV may occur late in pregnancy or during delivery.
Journal ArticleDOI
The relationship of the duration of ruptured membranes to vertical transmission of human immunodeficiency virus
Howard Minkoff,David N. Burns,Sheldon Landesman,Joan Youchah,James J. Goedert,Robert P. Nugent,Larry R. Muenz,Anne Willoughby +7 more
TL;DR: In this urban North American cohort women with low CD4 + levels were significantly more likely to transmit human immunodeficiency virus to their offspring if the duration of rupture of membranes was ≥4 hours.
Journal ArticleDOI
Blood Culture In The First 6 Months Of Life For The Diagnosis Of Vertically Transmitted Human Immunodeficiency Virus Infection
Kenneth McIntosh,Jane Pitt,Donald Brambilla,S Carroll,Clemente Diaz,Edward Handelsman,J Moye,Kenneth Rich +7 more
TL;DR: Serial blood cultures over the first 6 months of life in 310 infants with vertical exposure to human immunodeficiency virus (HIV) in the Women and Infants Transmission Study were analyzed to determine their value for early diagnosis of HIV infection.
References
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Journal ArticleDOI
Use of the Polymerase Chain Reaction for Early Detection of the Proviral Sequences of Human Immunodeficiency Virus in Infants Born to Seropositive Mothers
Martha F. Rogers,Chin-Yih Ou,Rayfield M,Polly Thomas,Ellie E. Schoenbaum,Elaine J. Abrams,Keith Krasinski,Peter A. Selwyn,Janet Moore,A Kaul +9 more
TL;DR: The polymerase chain reaction is used, a new technique that amplifies proviral sequences of HIV within DNA, to detect HIV infection in peripheral-blood mononuclear cells obtained from infants of seropositive women during the neonatal and postneonatal periods.
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Seroprevalence of human immunodeficiency virus among childbearing women. Estimation by testing samples of blood from newborns.
Rodney Hoff,Victor P. Berardi,Barbara J. Weiblen,Laurene Mahoney-Trout,Marvin L. Mitchell,George F. Grady +5 more
TL;DR: Using the newborn's blood as an indicator of the mother's serologic status, it is concluded that 1 of every 476 women giving birth in Massachusetts was positive for HIV antibody by immunofluorescence assay or enzyme-linked immunosorbent assay, both confirmed by immunoblot (Western blot) testing.
Journal ArticleDOI
Human immunodeficiency virus infection in children
TL;DR: Recherche des connaissances actuelles sur l'epidemiologie, le diagnostic chez l'enfant, l'etiologies, les manifestations cliniques tres diverses, le pronostic.
Journal ArticleDOI
Infants born to mothers seropositive for human immunodeficiency virus. Preliminary findings from a multicentre European study.
TL;DR: It is suggested that the risk of AIDS/ARC is higher in infants born to mothers who have AIDS symptoms during pregnancy and mode of delivery or breast-feeding.