Early Myocardial Strain Changes During Potentially Cardiotoxic Chemotherapy May Occur as a Result of Reductions in Left Ventricular End-Diastolic Volume: The Need to Interpret Left Ventricular Strain With Volumes.
Jennifer H. Jordan,Bunyapon Sukpraphrute,Giselle C. Meléndez,Marie-Pierre Jolly,Ralph B. D'Agostino,W. Gregory Hundley +5 more
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TLDR
To determine the frequency with which decrements in myocardial strain were mediated by decreases in LVEDV versus increases in LVESV in patients receiving potentially cardiotoxic chemotherapy, magnetic resonance examinations were performed both before and 3 months after the initiation of cancer treatment.Abstract:
Cardiac dysfunction and myocellular injury from cancer therapeutics are identified by reductions in left ventricular (LV) ejection fraction (LVEF) or >15% deteriorations in myocardial strain.1 Myocardial strain may deteriorate as a result of increases in LV end-systolic volume (LVESV), reductions in LV end-diastolic volume (LVEDV), or both. Decreases in LVEDV caused by hypovolemia from poor oral intake, emesis, or myocardial loss2 occur during cancer treatment. We sought to determine the frequency with which decrements in myocardial strain were mediated by decreases in LVEDV versus increases in LVESV in patients receiving potentially cardiotoxic chemotherapy.
The study was approved by the local institutional review board, and participants provided witnessed, written informed consent. Cardiovascular magnetic resonance examinations were performed on a 1.5-T Siemens Avanto scanner <6 hours before chemotherapy administration both before and 3 months after the initiation of cancer treatment. LV volumes, LVEF, LV mass, relative wall thickness, and midwall eulerian circumferential strain (ECC) were calculated from a series of LV short-axis white-blood cine stacks and a midcavity short-axis grid-tagged image.3 In addition, global longitudinal strain (GLS) was assessed from high-temporal-resolution 2- and 4-chamber cine views …read more
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Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations
Giuseppe Curigliano,Daniel J. Lenihan,Michael G. Fradley,Sarju Ganatra,Ana Barac,Anne H. Blaes,Jörg Herrmann,Charles B. Porter,Alexander R. Lyon,Patrizio Lancellotti,Aarti Patel,Jeanne M. DeCara,Joshua D. Mitchell,Eric E. Harrison,Javid Moslehi,Ronald M. Witteles,Maria Grazia Calabrò,Roberto Orecchia,E. de Azambuja,J. L. Zamorano,Ron Krone,Zaza Iakobishvili,Joseph R. Carver,Saro H. Armenian,Bonnie Ky,Daniela Cardinale,Carlo M. Cipolla,Susan Dent,Karin Jordan +28 more
TL;DR: Common CV toxicities related to cancer therapy are defined, along with suggested strategies for prevention, detection and treatment, and guidance regarding prevention, screening, monitoring and treatment of CV toxicity is provided.
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Multi-Modality Imaging in the Assessment of Cardiovascular Toxicity in the Cancer Patient.
Juan Carlos Plana,Paaladinesh Thavendiranathan,Chiara Bucciarelli-Ducci,Patrizio Lancellotti +3 more
TL;DR: Stress echocardiography, stress CMR, computed tomography, and PET are excellent imaging options in the evaluation of ischemia in patients receiving therapies that could potentially cause vasospasm or accelerated atherosclerosis.
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Cardiovascular Magnetic Resonance in the Oncology Patient
TL;DR: Prior research involving cardiovascular magnetic resonance for assessing cardiovascular disease in patients with or previously having received treatment for cancer is outlined and described.
Journal ArticleDOI
Myocardial strain imaging by cardiac magnetic resonance for detection of subclinical myocardial dysfunction in breast cancer patients receiving trastuzumab and chemotherapy
Geraldine Ong,Christine Brezden-Masley,Vinita Dhir,Djeven P. Deva,Djeven P. Deva,Kelvin K. W. Chan,Kelvin K. W. Chan,Chi-Ming Chow,Chi-Ming Chow,Dinesh Thavendiranathan,Dinesh Thavendiranathan,Rashida Haq,Rashida Haq,Joseph Barfett,Joseph Barfett,Teresa M Petrella,Teresa M Petrella,Kim A. Connelly,Kim A. Connelly,Andrew T. Yan,Andrew T. Yan +20 more
TL;DR: There was a significant reduction in LV strain during trastuzumab treatment, which correlated with a concurrent subtle decline in LVEF and was associated with an increase in LV end-diastolic volume.
Journal ArticleDOI
Contemporary Role of Echocardiography for Clinical Decision Making in Patients During and After Cancer Therapy
Jennifer E. Liu,Jose Banchs,Negareh Mousavi,Juan Carlos Plana,Marielle Scherrer-Crosbie,Paaladinesh Thavendiranathan,Ana Barac +6 more
TL;DR: Practical guidance on the role and use of echocardiography in challenging clinical cases in cardio-oncology is provided, with global longitudinal strain emerging as a promising tool in informing and facilitating the selection of cancer treatment and optimizing cardiovascular outcomes.
References
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Journal ArticleDOI
Expert Consensus for Multimodality Imaging Evaluation of Adult Patients during and after Cancer Therapy: A Report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.
Juan Carlos Plana,Maurizio Galderisi,Ana Barac,Michael S. Ewer,Bonnie Ky,Marielle Scherrer-Crosbie,Javier Ganame,Igal A. Sebag,Deborah A. Agler,Luigi P. Badano,Jose Banchs,Daniela Cardinale,Joseph R. Carver,Manuel D. Cerqueira,Jeanne M. DeCara,Thor Edvardsen,Scott D. Flamm,Thomas Force,Brian P. Griffin,Guy Jerusalem,Jennifer E. Liu,Andreia Magalhaes,Thomas H. Marwick,Liza Y. Sanchez,Rosa Sicari,Hector R. Villarraga,Patrizio Lancellotti +26 more
TL;DR: The noninvasive evaluation of LVEF has gained importance, and notwithstanding the limitations of the techniques used for its calculation, has emerged as the most widely used strategy for monitoring the changes in cardiac function, both during and after the administration of potentially car- diotoxic cancer treatment.
Journal ArticleDOI
Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.
Juan Carlos Plana,Maurizio Galderisi,Ana Barac,Michael S. Ewer,Bonnie Ky,Marielle Scherrer-Crosbie,Javier Ganame,Igal A. Sebag,Deborah A. Agler,Luigi P. Badano,Jose Banchs,Daniela Cardinale,Joseph R. Carver,Manuel D. Cerqueira,Jeanne M. DeCara,Thor Edvardsen,Scott D. Flamm,Thomas Force,Brian P. Griffin,Guy Jerusalem,Jennifer E. Liu,Andreia Magalhaes,Thomas H. Marwick,Liza Y. Sanchez,Rosa Sicari,Hector R. Villarraga,Patrizio Lancellotti +26 more
TL;DR: The non-invasive evaluation of LVEF has gained importance, and notwithstanding the limitations of the techniques used for its calculation, has emerged as the most widely used strategy for monitoring the changes in cardiac function, both during and after the administration of potentially cardiotoxic cancer treatment.
Journal ArticleDOI
Low to Moderate Dose Anthracycline-Based Chemotherapy Is Associated With Early Noninvasive Imaging Evidence of Subclinical Cardiovascular Disease
Brandon C. Drafts,Katie M. Twomley,Ralph B. D'Agostino,Julia Lawrence,Nancy E. Avis,Leslie R. Ellis,Vinay Thohan,Jennifer H. Jordan,Susan A. Melin,Frank M. Torti,William C. Little,Craig A. Hamilton,W. Gregory Hundley +12 more
TL;DR: In 53 men and women with breast cancer, leukemia, or lymphoma, low to moderate doses of Anth-bC were associated with the early development of subclinical abnormalities of cardiac and vascular function that in other populations areassociated with the future occurrence of CV events.
Journal ArticleDOI
Effect of preload on left ventricular longitudinal strain by 2D speckle tracking.
Jin-Oh Choi,Dae-Hee Shin,Sung Won Cho,Young Bin Song,Jun Hyung Kim,Yoon Goo Kim,Sang-Chol Lee,Seung Woo Park +7 more
TL;DR: PSLS obtained from the 2D strain profile is a reliable parameter that may be useful for evaluating LV systolic long‐axis function, but it should be applied cautiously in ESRD patients because it could be affected by dialysis.
Journal ArticleDOI
End-systolic elastance and ventricular-arterial coupling reserve predict cardiac events in patients with negative stress echocardiography
Tonino Bombardini,Marco Fabio Costantino,Rosa Sicari,Quirino Ciampi,Lorenza Pratali,Eugenio Picano +5 more
TL;DR: Patients with negative stress echocardiography may experience an adverse outcome, which can be identified by assessment of E LVI reserve and VAC reserve during stress echo, which are identified by receiver-operating-characteristic curves.
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