Journal ArticleDOI
Effect of light history on retinal antioxidants and light damage susceptibility in the rat
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TLDR
Electroretinographic evaluation supports morphometrical findings that Animals raised in 800-lx cyclic light have a significant increase in the retinal activities of the three glutathione enzymes over activities measured in animals raised in the two dimmer regimes.About:
This article is published in Experimental Eye Research.The article was published on 1987-06-01. It has received 160 citations till now. The article focuses on the topics: Glutathione peroxidase & Glutathione reductase.read more
Citations
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The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
TL;DR: The concept that AMD can be attributed to cumulative oxidative stress is enticing, but remains unproven, and the effect of nutritional antioxidant supplements on the onset and natural course of age-related macular disease is currently being evaluated.
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Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins
TL;DR: The combination of evidence suggests that carotenoids and antioxidant vitamins may help to retard some of the destructive processes in the retina and the retinal pigment epithelium that lead to age-related degeneration of the macula.
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Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects.
Andreas Bringmann,Ianors Iandiev,Thomas Pannicke,Antje Wurm,Margrit Hollborn,Peter Wiedemann,Neville N. Osborne,Andreas Reichenbach +7 more
TL;DR: An overview of the neuroprotective and detrimental effects of Müller cell gliosis is provided, with accounts on the cellular signal transduction mechanisms and factors which are implicated in Müllercell-mediated neuroprotection, immunomodulation, regulation of Müllers cell proliferation, upregulation of intermediate filaments, glial scar formation, and the generation of neural progenitor/stem cells.
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New functions of Müller cells.
TL;DR: This review gives a survey of recently discoved new functions of Müller cells, living optical fibers that guide light through the inner retinal tissue that enhance the signal/noise ratio by minimizing intraretinal light scattering and conserve the spatial distribution of light patterns in the propagating image.
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Retinal light damage: mechanisms and protection.
TL;DR: The salient features of light damage are reviewed, recently joined by evidence for retinal remodeling which has implications for the prognosis of recovery of function in retinal degenerations and select factors that influence the progression of the damage process and the extent of visual cell loss are considered.
References
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Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
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Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
TL;DR: Glutathione peroxidase activity is found to be associated with a relatively stable, nondialyzable, heat-labile, intracellular component which is separable from hemoglobin, by gel filtration and ammonium sulfate precipitation.
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Direct observation of a free radical interaction between vitamin E and vitamin C
TL;DR: Direct observation of the interaction between vitamin E and vitamin C and the resulting vitamin E radical then reacting with vitamin C to regenerate vitamin E is reported, which is felt to be an important feature in the maintenance of vitamin E levels in tissues.
Journal Article
Retinal damage by light in rats
TL;DR: The retina of laboratory rats is affected irreversibly by intense light applied for less than 1 hour or for up to 2 days depending upon experimental conditions, and the action spectrum of the daviaging effect approximated that of visual excitation as measured by the ERG.
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Simultaneous determination of alpha-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography.
TL;DR: Compared with conventional methods for these vitamins, the rapid, microprocedure for the simultaneous determination of alpha-tocopherol and retinol in plasma and alone in red cells gave excellent agreement with conventional Methods.