Journal ArticleDOI
Effects of copper on mammalian cell components
TLDR
The ability to chelate Cu(II) ions is seen to be of the order: purine > purine ribonucleotides, purine nucleoside > pyrimidine ribon nucleotides.About:
This article is published in Chemico-Biological Interactions.The article was published on 1989-01-01. It has received 93 citations till now. The article focuses on the topics: Purine & Copper.read more
Citations
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Journal ArticleDOI
Copper toxicity, oxidative stress, and antioxidant nutrients.
Lisa M. Gaetke,Ching Kuang Chow +1 more
TL;DR: Results obtained from available animal studies suggest that the compound is protective, and further studies are needed to better understand the cellular effects of this essential, but potentially toxic, trace mineral and its functional interaction with other nutrients.
Journal ArticleDOI
Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications.
TL;DR: The present paper is intended to provide the reader up-to-date information on the antioxidant and pro-oxidant properties of resveratrol and its clinical implications and proposed mechanism for anticancer and chemopreventive properties of plant polyphenols.
Journal ArticleDOI
Molecular Mechanisms of Estrogen Carcinogenesis
James D. Yager,J G Liehr +1 more
TL;DR: The examples demonstrate that the parent compounds and their metabolites cause both nongenotoxic cell proliferative effects as well as direct and indirect genotoxic effects, which illustrates the complex nature of estrogen carcinogenesis.
Journal ArticleDOI
Resveratrol: A Double-Edged Sword in Health Benefits
Bahare Salehi,Abhay Prakash Mishra,Manisha Nigam,Bilge Sener,Mehtap Kilic,Mehdi Sharifi-Rad,Patrick Valere Tsouh Fokou,Natália Martins,Javad Sharifi-Rad,Javad Sharifi-Rad +9 more
TL;DR: This review summarized current data on resveratrol pharmacological effects and confirmed its anticancer properties, as well as other bioactive effects, namely as anti-inflammatory, anticarcinogenic, cardioprotective, vasorelaxant, phytoestrogenic and neuroprotective.
Journal ArticleDOI
Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): implications for PCB-induced oxidative stress in breast cancer.
TL;DR: Examination of PCB metabolites to induce free radical-mediated oxidative DNA damage using a newly developed, highly sensitive, 32P-postlabeling assay for 8-oxode-oxyguanosine demonstrates that free radicals and oxidative DNADamage are produced during oxidation of lower chlorinated biphenyls.
References
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Journal ArticleDOI
Short-term tests for carcinogens and mutagens
Journal ArticleDOI
Metabolism and possible health effects of aluminum.
TL;DR: A hypothetical model is presented for the metabolism of aluminum, based on documented direct observations of Al3+ and analogies from other ions, and it is proposed that an accumulation may take place at a subcellular level without any significant increase in the corresponding tissue concentration.
Journal ArticleDOI
Infidelity of DNA synthesis in vitro: screening for potential metal mutagens or carcinogens.
TL;DR: All ten salts of metal carcinogens decreased the fidelity of DNA synthesis, and 17 noncarcinogenic metal salts did not affect fidelity even when present at concentrations that were clearly inhibitory.
Journal ArticleDOI
The Effect of Electrolytes on the Stability of the Deoxyribonucleate Helix
Journal ArticleDOI
Menkes' kinky-hair syndrome.
TL;DR: Gross changes in free sulphydryl groups in hair keratin probably explain the kinky hair, and treatment of Menkes' syndrome may become possible as a result of these findings.
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