Journal ArticleDOI
Effects of NMDA antagonists on developmental plasticity in kitten visual cortex.
TLDR
A mechanism for the correlation of activity in simultaneously active pre‐ and postsynaptic neurons could be provided by the properties of the N‐methyl‐d‐aspartate (NMDA) receptor and its associated Ca2+ channel, which opens in a transmitter‐ and voltage‐dependent manner.About:
This article is published in International Journal of Developmental Neuroscience.The article was published on 1990-01-01. It has received 51 citations till now. The article focuses on the topics: NMDA receptor & Visual cortex.read more
Citations
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Journal ArticleDOI
Roles of NMDA receptor activity and nitric oxide production in brain development
TL;DR: Experimental evidence for a correlated role of the activity of the NMDA receptor and the production of NO in key steps of neural development is reviewed, and some of the major controversial issues are addressed and, in some cases, suggestions for possible future experiments are proposed.
Journal ArticleDOI
N-methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map.
TL;DR: Results indicate that, at a stage preceding visually evoked activity, normal NMDA receptor function is important for the development of an ordered neural map in the mammalian brain.
Journal ArticleDOI
Enhanced Excitability of the Human Visual Cortex Induced by Short-term Light Deprivation
Babak Boroojerdi,Khalaf Bushara,Brian Corwell,Ilka Immisch,Fortunato Battaglia,Wolf Muellbacher,Leonardo G. Cohen +6 more
TL;DR: A substantial increase in visual cortex excitability was demonstrated after a short period of light deprivation, which may underlie behavioral gains reported in humans and animals associated with light deprivation.
Journal ArticleDOI
Mechanisms of sleep-dependent consolidation of cortical plasticity.
Sara J. Aton,Julie Seibt,Michelle C. Dumoulin,Sushil K. Jha,Sushil K. Jha,Nicholas A. Steinmetz,Tammi Coleman,Nirinjini Naidoo,Marcos G. Frank +8 more
TL;DR: It is found that sleep consolidates ODP primarily by strengthening cortical responses to nondeprived eye stimulation, and synaptic strengthening via NMDAR and PKA activity is a key step in sleep-dependent consolidation of ODP.
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Nitric oxide donors enhance neurotrophin-induced neurite outgrowth through a cGMP-dependent mechanism.
Shaun Hindley,Bernhard H.J. Juurlink,J.W. Gysbers,Pamela J. Middlemiss,Mary A. Herman,Michel P. Rathbone +5 more
TL;DR: Investigation of whether NO stimulated neurite outgrowth from hippocampal neurons and PC12 cells suggested that NO may act alone or with other growth factors to regulate synapse formation and maintenance by stimulating neuriteOutgrowth.
References
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Journal ArticleDOI
Receptive fields, binocular interaction and functional architecture in the cat's visual cortex
David H. Hubel,Torsten N. Wiesel +1 more
TL;DR: This method is used to examine receptive fields of a more complex type and to make additional observations on binocular interaction and this approach is necessary in order to understand the behaviour of individual cells, but it fails to deal with the problem of the relationship of one cell to its neighbours.
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Single-cell responses in striate cortex of kittens deprived of vision in one eye.
Torsten N. Wiesel,David H. Hubel +1 more
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The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
Erik H. F. Wong,John A. Kemp,Tony Priestley,Antony R. Knight,Geoffrey Neil Woodruff,L. L. Iversen +5 more
TL;DR: Neurophysiological studies in vitro, using a rat cortical-slice preparation, demonstrated a potent, selective, and noncompetitive antagonistic action of MK-801 on depolarizing responses to N-Me-D-Asp but not to kainate or quisqualate, providing an explanation for the mechanism of action ofMK-801 as an anticonvulsant.