Showing papers in "International Journal of Developmental Neuroscience in 1990"

TL;DR: It is suggested that glia surface‐associated FGF may play important roles in hippocampal development, and in neurodegenerative conditions that involve EAAs.

TL;DR: Intracellular recordings from rat hippocampal neurons in vitro during the first postnatal week revealed the presence of spontaneous giant depolarizing potentials (GDPs), which were generated by the synchronous discharge of a population of neurons.

TL;DR: It is concluded that the EAA‐induced cytotoxicity is strictly related to the glutamate receptor subtype expression in the neurons and it seems justified to conclude that QA and AMPA do not have strictly analogous actions.

TL;DR: These results have demonstrated direct trophic effects of RA on spinal cord neurons and have suggested another role for astrocytes in the maintenance of normal neural physiology by regulating RA concentrations through the oxidation of retinol.

TL;DR: In intrauterine growth retardation there is a delay in the initiation and in the extent of myelination, which could be due to a reduction in the number ofMyelinating glia formed and the restricted capacity of those which do form to generate myelin.

TL;DR: Two separate catecholaminergic groups could be visualized, although many TH positive cells with long neurites (putative dopaminergic neurons) could still be seen at the edges of the ventricle, and appeared to be moving towards the ventral mesencephalon.

TL;DR: Compared choline acetyltransferase activity (as a structural marker) and sodium‐dependent high affinity choline uptake (which reflects both ongoing cholinergic neuronal activity and structural integrity) in the hippocampus, cortex and striatum of male C57BL mice at 3–4, 10–12 or 28–32 months of age.

TL;DR: Differences in effects on specific neurotransmitter systems reflect the fact that the forebrain is most severely affected by early ethanol administration, whereas the hindbrain is relatively spared, which could explain some of the functional deficits observed in children with FAS.

TL;DR: The data suggest that GABAA‐receptors may be involved in the GABA‐induced neurite elongation in serum‐supplemented medium only, although this subtype of receptors is present in serumfree conditions as well as revealed in binding studies using [3H]muscimol.

TL;DR: In order to study the effects of a neonatal dopamine lesion on dopaminergic, serotonergic and peptidergic systems, Sprague‐Dawley rats were treated by intracerebroventricular administration of 6‐hydroxydopamine following desipramine pretreatment.

TL;DR: It is demonstrated that proNGF‐like immunoreactivity is localized within neuronal cell bodies, in the cortex, hippocampus and septum, which suggests that the immunological approach may not only identify NGF‐synthesizing cells, but also cells which may accumulate pro NGF or some cleavage products by an uptake mechanism.

TL;DR: This work has attempted to elucidate the mechanism(s) underlying the trophic effect of KA, and its role in cell differentiation and apoptosis.

TL;DR: A mechanism for the correlation of activity in simultaneously active pre‐ and postsynaptic neurons could be provided by the properties of the N‐methyl‐d‐aspartate (NMDA) receptor and its associated Ca2+ channel, which opens in a transmitter‐ and voltage‐dependent manner.

TL;DR: It is suggested that NA release from NA nerve terminals responsive to depolarization is reduced inSAM‐P/8 at an earlier stage than in SAM‐R/1, and NMDA receptors which could be localized in the soma and/or nerve terminals seem to be involved in NA release.

TL;DR: Dynamic changes in nicotinic receptor properties during life span of rodents are illustrated by 3H‐nicotine binding showed different temperature dependence in rat brain of different ages.

TL;DR: The results rule out the possibility that horizontal cells provide a structural barrier which is an absolute requirement for establishing the location of the outer plexiform layer, rather, these cells may be more involved in cell differentation and synaptogenesis.

TL;DR: The data indicate that excitatory amino acids have more than one action that can influence neuronal survival during development and that VIP can increase neuronal survival in bioelectrically active cultures when NMDA channels are blocked.

TL;DR: Increases in the concentrations of galanin‐like immunoreactivity during maturation of the animals closely paralleled the immunohistochemical findings.

TL;DR: The results indicate that, in the immature cerebral cortex, NMDA receptors may be primarily involved in synaptic transmission, whereas quisqualate and kainate receptors may play some other (e.g. trophic) roles.

TL;DR: The results strongly suggest that the hyper‐polarizing action of GABA via the chloride channels coupled to high affinity GABA receptors is the permissive signal for initiation of further reactions involved in the trophic and differentiating actions of GABA.

TL;DR: The developmental profiles for binding of α‐[125I]bungarotoxin and l‐[3H]nicotine to putative nicotinic cholinergic receptors were determined in seven mouse brain regions and in most of the brain regions the developmental profile for α‐bungARotoxin binding was different from that of nicotine.

TL;DR: In this article, a detailed knowledge of regional neurochemical brain maturation is provided, which gives us information concerning some key events of brain development, and this knowledge is the essential pre-requisite for studies aimed at the alteration of specific regional and temporal parameters through experimental manipulation.

TL;DR: The distribution of nChE activity in the developing peripheral nerves of chick embryos suggests that these molecules may influence the process of axonal elongation and locomotion.

TL;DR: Assessment of antiproliferative activity of anticonvulsant drugs may be one criterion for identification of teratogenic potential during neurulation.

TL;DR: Using the immunofluorescence technique, three populations of fibers staining for calcitonin gene‐related peptide‐like immunostained fibers are identified in postnatal developing cochleas and in adult rat cochreas.

TL;DR: Epidermal growth factor has a clear direct interaction with glial fibrillary acidic protein‐containing cells which is greater in higher density cultures, is still present in long‐quiescent cells, and includes DNA synthesis, cell cycle progression, hexose uptake, and polyamine synthesis.

TL;DR: The distribution of specific markers of polarity and function shows a typical differentiation with maintenance of polarized features in choroidal ependymocytes in culture, testifying that this cell culture system constitutes an interesting model for studying the functional characteristics of ependedymal cells of the choroid plexus.

TL;DR: The developmental pattern of l‐[3H]glutamate binding to rat brain in the presence of saturating concentrations of unlabeled N‐methyl‐d‐aspartate (NMDA), kainate (KA) and quisqualate (OQA) was examined in an autoradiographic assay, suggesting that it may be important in normal development of the central nervous system.

TL;DR: The hypothesis that GABA is a putative neurotransmitter that could be used by subpopulations of the two olivocochlear innervations is strengthened and it is suggested that GABA either plays a neurotrophic function or participates in the regulation of the first cochlear potentials at the level of lateral efferent synapses.

TL;DR: It is suggested that aging is associated with alterations in the motor axon to the EDL muscle that are manifest at the neuromuscular junction and which the muscle responds as if it were in a state of functional denervation.