Efficacy and appropriateness of novel antibiotics in response to antimicrobial-resistant Gram-negative bacteria in patients with sepsis in the ICU.
TLDR
There is an ever-increasing range of antibiotic-resistant pathogens that have led to higher community-acquired infections, and substantial mortality rates in critically ill patients as discussed by the authors, and this has led to the need for new antibiotics.Abstract:
There is an ever-increasing range of antibiotic-resistant pathogens that have led to higher community-acquired infections, and substantial mortality rates in critically ill patients.We have critica...read more
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Novel investigational treatments for ventilator-associated pneumonia and critically ill patients in the intensive care unit
TL;DR: Novel approaches such as monoclonal antibody treatments for P. aeruginosa and S. aureus and phage antibiotic synthesis are highlighted and mechanisms of resistance in Gram-negative bacteria, virulence factors, and inhaled antibiotics are examined.
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Ventilator-associated pneumonia in critically ill patients with COVID-19 infection: a narrative review
TL;DR: Critically ill COVID-19 patients are at risk of developing VAP for several reasons, which increases their overall mortality, and it is recommended to recommend the use of invasive techniques when possible.
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Laboratory Diagnosis of Carbapenemase-producing Enterobacterales
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Comparative Analysis of Short-Course Vs Long Course Antibiotic Therapy among Patients with Complicated Intra-Abdominal Infections
TL;DR: It can be concluded that the short course antibiotic therapy has good efficacy to treat CIAI when the primary foci of infection are surgically extracted with adequate source control.
References
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Journal ArticleDOI
International Study of the Prevalence and Outcomes of Infection in Intensive Care Units
Jean Louis Vincent,Jordi Rello,John C. Marshall,Eliezer Silva,Antonio Anzueto,Claude Martin,Rui Moreno,Jeffrey Lipman,Charles D. Gomersall,Yasser Sakr,Konrad Reinhart +10 more
TL;DR: In this large cohort, infection was independently associated with an increased risk of hospital death and risk of infection increases with duration of ICU stay.
Journal ArticleDOI
Global increase and geographic convergence in antibiotic consumption between 2000 and 2015.
Eili Y. Klein,Eili Y. Klein,Thomas P. Van Boeckel,Elena Martinez,Suraj Pant,Sumanth Gandra,Simon A. Levin,Herman Goossens,Ramanan Laxminarayan,Ramanan Laxminarayan,Ramanan Laxminarayan +10 more
TL;DR: It is found that the antibiotic consumption rate in low- and middle- income countries (LMICs) has been converging to (and in some countries surpassing) levels typically observed in high-income countries, and projected total global antibiotic consumption through 2030 was up to 200% higher than the 42 billion DDDs estimated in 2015.
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Antibiotics For Emerging Pathogens
TL;DR: The emergence of multidrug resistance among the latest generation of pathogens suggests that the discovery of new scaffolds should be a priority, and promising approaches to scaffold discovery are emerging.
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Platforms for antibiotic discovery
TL;DR: Strategies to re-establish viable platforms for antibiotic discovery include investigating untapped natural product sources such as uncultured bacteria, establishing rules of compound penetration to enable the development of synthetic antibiotics, developing species-specific antibiotics and identifying prodrugs that have the potential to eradicate dormant persisters, which are often responsible for hard-to-treat infections.
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International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia
Antoni Torres,Michael S. Niederman,Jean Chastre,Santiago Ewig,Patricia Fernandez-Vandellos,Håkan Hanberger,Marin H. Kollef,Gianluigi Li Bassi,Carlos M. Luna,Ignacio Martin-Loeches,J. Artur Paiva,Robert C. Read,David Rigau,Jean-François Timsit,Tobias Welte,Richard G. Wunderink +15 more
TL;DR: The panel selected seven PICO (population–intervention–comparison–outcome) questions that generated a series of recommendations for HAP/VAP diagnosis, treatment and prevention that were adopted by the ERS/ESICM/ESCMID/ALAT panel.
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