Journal ArticleDOI
Efficient Synthesis of Spiro[chromeno[2,3-d]pyrimidine-5,3′-indoline]-tetraones by a One-Pot and Three-Component Reaction
TLDR
An efficient one-pot synthesis of novel 8,9-dihydrospiro[chromeno[2,3-d]pyrimidine-5,3'-indoline]-2,2',4,6(1H,3H,7H)-tetraone derivatives by a three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3Abstract:
An efficient one-pot synthesis of novel 8,9-dihydrospiro[chromeno[2,3-d]pyrimidine-5,3′-indoline]-2,2′,4,6(1H,3H,7H)-tetraone derivatives by a three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3-diones in refluxing water in the presence of p-TSA for 10 h is reported. Two cyclohexane-1,3-diones, three barbituric acids, and eight substituted isatins were chosen for the library validation. Reaction of 5,5-dimethyl-cyclohexane-1,3-dione and acenaphthylene-1,2-dione with barbituric acids resulted in the formation of spiro[acenaphthylene-1,5′-chromeno[2,3-d]pyrimidine] derivatives.read more
Citations
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Journal ArticleDOI
Molecular diversity of spirooxindoles. Synthesis and biological activity
TL;DR: This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work.
Journal ArticleDOI
Efficient one-pot synthesis of spirooxindole derivatives catalyzed by L-proline in aqueous medium.
TL;DR: An efficient one-pot synthesis of spirooxindole derivatives by three-component reaction of isatins, malononitrile and 1,3-dicarbonyl compounds in water in the presence of l-proline is reported.
Journal ArticleDOI
Recent Advances in Diversity Oriented Synthesis through Isatin-based Multicomponent Reactions
TL;DR: Isatins are well-known carbonyl electrophiles which allow a vast number of reactions initiated by nucleophilic attack on the C3 carbonyls group when used as starting materials as discussed by the authors.
Journal ArticleDOI
Rapid and efficient ultrasound-assisted method for the combinatorial synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives.
Yi Zou,Yu Hu,Hai Liu,Daqing Shi +3 more
TL;DR: This one-pot synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives by four-component reaction of hydrazine, β-keto ester, isatin, and malononitrile catalyzed by piperidine under ultrasound irradiation is described.
Journal ArticleDOI
Efficient One-Pot Synthesis of Novel Spirooxindole Derivatives via Three-Component Reaction in Aqueous Medium
Hui Chen,Daqing Shi +1 more
TL;DR: A novel and efficient one-pot synthesis of spiro[indoline-3, 4'-pyrazolo[3,4-b]quinoline]dione, spiro,[furo[3-4-e]pyrazole]dion, and spiro [indeno[2,1-e], pyridine-4,3'-indoline]-dione derivatives via three-component reaction of isatin, 5-amino-3-methylpy
References
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