Journal ArticleDOI
Efflux pumps in Mycobacterium tuberculosis and their inhibition to tackle antimicrobial resistance.
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TLDR
A review summarises the current state of knowledge surrounding drug-related efflux pumps in M. tuberculosis and presents recent updates within the field of mycobacterial EPIs with a view to aiding the design of an effective adjunct therapy to overcome efflux-mediated resistance in TB as discussed by the authors.About:
This article is published in Trends in Microbiology.The article was published on 2021-05-26. It has received 17 citations till now. The article focuses on the topics: Efflux & Mycobacterium tuberculosis.read more
Citations
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Journal ArticleDOI
Anti-tuberculosis treatment strategies and drug development: challenges and priorities
Véronique Dartois,Eric J. Rubin +1 more
TL;DR: In this paper , the benefits and challenges of 'one-size-fits-all' regimens and treatment duration versus individualized therapy based on disease severity and host and pathogen characteristics, considering scientific and operational perspectives.
Journal ArticleDOI
Non-Coding RNAs in Tuberculosis Epidemiology: Platforms and Approaches for Investigating the Genome’s Dark Matter
TL;DR: A viewpoint is presented on the key challenges and novel techniques for the future and for a wide-ranging therapeutic application of ncRNAs for the treatment of tuberculosis.
Journal ArticleDOI
Luteolin increases susceptibility to macrolides by inhibiting MsrA efflux pump in Trueperella pyogenes
Yuli Guo,Cheng-zhen Huang,Hongyu Su,Zehui Zhang,Menghan Chen,Ruxia Wang,Dexian Zhang,Luyao Zhang,Mingchun Liu +8 more
TL;DR: In this article , the effect of luteolin on the MsrA efflux pump was investigated and the results of an affinity test showed that the equilibrium dissociation constant (KD) was 6.462 × 10-5 M.
Journal ArticleDOI
Advances in the design of combination therapies for the treatment of tuberculosis
TL;DR: A recent review as mentioned in this paper discusses the advances in these methodologies and how they may be used in conjunction with new successful clinical trials of novel drug combinations to design optimized combination therapies for tuberculosis.
Journal ArticleDOI
Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis
TL;DR: In this paper , the authors focus on the major gaps in our understanding of intrinsic drug resistance in Mycobacterium tuberculosis and how functional and chemical-genetics can help close those gaps.
References
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Journal ArticleDOI
Mechanisms of Antimicrobial Resistance in Bacteria
TL;DR: 3 case histories-one involving Escherichia coli resistance to third-generation cephalosporins, another focusing on the emergence of vancomycin-resistant Staphylococcus aureus, and a third detailing multidrug resistance in Pseudomonas aeruginosa--are reviewed to illustrate the varied ways in which resistant bacteria develop.
Journal ArticleDOI
Structure and Mechanism of the Glycerol-3-Phosphate Transporter from Escherichia Coli
TL;DR: This work reports the 3.3 angstrom resolution structure of a member of the major facilitator superfamily, GlpT, which transports glycerol-3-phosphate into the cytoplasm and inorganic phosphate into the periplasm and proposes that it operates by a single–binding site, alternating-access mechanism through a rocker-switch type of movement.
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The importance of efflux pumps in bacterial antibiotic resistance
TL;DR: Efflux pumps are transport proteins involved in the extrusion of toxic substrates from within cells into the external environment and in eukaryotic organisms.
Journal ArticleDOI
Multidrug efflux pumps: structure, function and regulation
Dijun Du,Xuan Wang-Kan,Arthur Neuberger,Hendrik W. van Veen,Klaas M. Pos,Laura J. V. Piddock,Ben F. Luisi +6 more
TL;DR: Recent advances that have increased understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria are described, suggesting opportunities for countering their activities.
Journal ArticleDOI
Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis
TL;DR: In this paper, mutations in the transcriptional regulator Rv0678, with concomitant upregulation of the multisubstrate efflux pump, MmpL5, accounted for this cross-resistance.
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