Journal ArticleDOI
Enantioselective aza-Henry reaction catalyzed by a bifunctional organocatalyst.
TLDR
The aza-Henry reaction of imines with nitroalkanes was promoted by chiral thiourea with an N,N-dimethylamino group to give beta-nitroamines with good enantioselectivity.About:
This article is published in Organic Letters.The article was published on 2004-01-27. It has received 326 citations till now. The article focuses on the topics: Nitroaldol reaction & Thiourea organocatalysis.read more
Citations
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Journal ArticleDOI
Small-molecule H-bond donors in asymmetric catalysis.
Journal ArticleDOI
Asymmetric catalysis by chiral hydrogen-bond donors.
Mark S. Taylor,Eric N. Jacobsen +1 more
TL;DR: This review documents the structural and mechanistic features that contribute to high enantioselectivity in hydrogen-bond-mediated catalytic processes in small-molecule, synthetic catalyst systems.
Journal ArticleDOI
Organocatalytic ring-opening polymerization.
Nahrain E. Kamber,and Wonhee Jeong,Robert M. Waymouth,Russell C. Pratt,and Bas G. G. Lohmeijer,James L. Hedrick +5 more
TL;DR: This paper presents the design of highly efficient families of “living” polymerization strategies for the synthesis of block, graft, and star polymers through controlled methods for the controlled synthesis of dendritic macromolecules.
Journal ArticleDOI
(Thio)urea organocatalysis—What can be learnt from anion recognition?
Zhiguo Zhang,Peter R. Schreiner +1 more
TL;DR: The present critical review outlines the close relationship and mutual interplay between molecular recognition, active site considerations in enzyme catalysis involving anions, and organocatalysis utilizing explicit hydrogen bonding.
Journal ArticleDOI
Enantio- and Diastereoselective Michael Reaction of 1,3-Dicarbonyl Compounds to Nitroolefins Catalyzed by a Bifunctional Thiourea
TL;DR: A new class of bifunctional catalysts bearing a thiourea moiety and an amino group on a chiral scaffold bearing 3,5-bis(trifluoromethyl)benzene and dimethylamino groups was revealed to be highly efficient for the asymmetric Michael reaction of 1,3-dicarbonyl compounds to nitroolefins.
References
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Journal ArticleDOI
Enantioselective Michael Reaction of Malonates to Nitroolefins Catalyzed by Bifunctional Organocatalysts
TL;DR: Michael reaction of malonates to nitrooleolefins with chiral bifunctional organocatalysts, bearing both a thiourea and tertiary amino group, afforded Michael adducts with high yields and enantioselectivities.
Journal ArticleDOI
Metal-free organocatalysis through explicit hydrogen bonding interactions
TL;DR: This field is briefly reviewed here, along with some rough guidelines and concepts for further catalyst development, which offers attractive alternatives to metal (ion)-catalyzed reactions by combining supramolecular recognition with chemical transformations in an environmentally benign fashion.
Journal ArticleDOI
The Reactions of Primary Nitroparaffins with Isocyanates1
Teruaki Mukaiyama,Toshio Hoshino +1 more
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Structure-based analysis and optimization of a highly enantioselective catalyst for the strecker reaction.
Petr Vachal,Eric N. Jacobsen +1 more
TL;DR: Rational optimization of catalyst structure based on the mechanistic insight led to an improved catalyst for the asymmetric Strecker reaction.