Journal ArticleDOI
Enantioselective Cu-catalyzed conjugate addition of diethylzinc to acyclic aliphatic enones.
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TLDR
A new P-chiral phosphine bis(sulfonamide) ligand has been developed that allows the Cu-catalyzed enantioselective conjugate addition of Et(2)Zn to acyclic aliphatic enones.About:
This article is published in Organic Letters.The article was published on 2004-10-08. It has received 47 citations till now. The article focuses on the topics: Enone & Diethylzinc.read more
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Enantioselective Copper-Catalyzed Conjugate Addition and Allylic Substitution Reactions
TL;DR: This paper presents a meta-analyses of the chiral stationary phase of Na6(CO3(SO4)(SO4)2, where Na2SO4 is a major component of the polymethine of carbon dioxide and its opposite, Na2CO3, which has an important role in the formation of DNA.
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Recent advances in enantioselective copper-catalyzed 1,4-addition.
TL;DR: A comprehensive overview of recent literature from 2003 concerning advances in enantioselective copper catalysed 1,4-addition of organometallic reagents to alpha,beta-unsaturated compounds is given in this critical review.
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Copper-catalyzed enantioselective conjugate addition of Grignard reagents to alpha,beta-unsaturated esters.
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Design and synthesis of new bidentate alkoxy-NHC ligands for enantioselective copper-catalyzed conjugate addition
TL;DR: In this paper, a new family of chiral alkoxy-N-heterocyclic carbene (NHC) ligands was designed for the enantioselective copper-catalyzed conjugate addition of dialkylzincs to enones.
References
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Journal ArticleDOI
Enantioselective Copper-Catalysed Conjugate Addition
Alexandre Alexakis,Cyril Benhaim +1 more
TL;DR: The review covers the efforts made over the last decade towards designing efficient copper-catalysed systems for the asymmetric conjugate addition reaction.
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Modular peptide-based phosphine ligands in asymmetric catalysis: efficient and enantioselective Cu-catalyzed conjugate additions to five-, six-, and seven-membered cyclic enones.
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Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to acyclic aliphatic enones.
TL;DR: The utility of the present method is not limited to reactions involving Et2Zn; a variety of alkylzincs may be used and many of the requisite substrates can be easily accessed through catalytic olefin cross metathesis.
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Development of New Chiral P,N Ligands and Their Application in the Cu-Catalyzed Enantioselective Conjugate Addition of Diethylzinc to Enones.
TL;DR: High enantioselectivity (up to 98 % ee) has been achieved for the conjugate addition of diethylzinc to acyclic enones utilizing Cu(I) complexes of the novel chiral P,N ligands 1.
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Catalytic asymmetric acyl halide-aldehyde cyclocondensation reactions of substituted ketenes.
TL;DR: Catalytic asymmetric acyl halide-aldehyde cyclocondensation reactions of alkyl-substituted ketenes with structurally diverse aldehydes provide cis-disubstituting beta-lactones with high enantioselectivity.