Journal ArticleDOI
Endocrine Disruption in Wildlife: A Critical Review of the Evidence
TLDR
The evidence, from both laboratory and field studies, that exposure to steroid hormone mimics may impair reproductive function is reviewed and the weight of evidence for endocrine disruption in wildlife is critically assessed.Abstract:
In recent years, a number of man-made chemicals have been shown to be able to mimic endogenous hormones, and it has been hypothesized that alterations in the normal pattern of reproductive development seen in some populations of wildlife are linked with exposure to these chemicals. Of particular importance are those compounds that mimic estrogens and androgens (and their antagonists), because of their central role in reproductive function. In fact, the evidence showing that such chemicals actually do mimic (or antagonize) the action of hormones in the intact animal is limited. In only a few cases have laboratory studies shown that chemicals that mimic hormones at the molecular level (in vitro) also cause reproductive dysfunction in vivo at environmentally relevant concentrations. In addition, the reported studies on wild populations of animals are limited to a very few animal species and they have often centered on localized 'hot-spots' of chemical discharges. Nevertheless, many of these xenobiotics are persistent and accumulate in the environment, and therefore a more widespread phenomenon of endocrine disruption in wildlife is possible. This article reviews the evidence, from both laboratory and field studies, that exposure to steroid hormone mimics may impair reproductive function and critically assesses the weight of evidence for endocrine disruption in wildlife.read more
Citations
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Journal ArticleDOI
Effect of oil pollution on serum growth hormone (GH) levels, histology and Ultrastructure of muscles of the Nile Tilapia (Oreochromis niloticus)
TL;DR: The results revealed that the River Nile transport project can lead to serious harm to fish community that eventually become unsafe for human consumption, and this project must be carefully revised forbidden by health agencies.
Journal ArticleDOI
GC-MS Determination of Targeted Pesticides in Environmental Samples from the Kafue Flats of Zambia
Kwenga Sichilongo,Daniel Banda +1 more
TL;DR: Results of a GC-MS analysis for targeted pesticides i.e. dieldrin, endosulfan, pp-DDT, endrin, HCB, heptachlor, mirex and aldrin in the Kafue Flats of Zambia are presented.
Journal ArticleDOI
Interacting effects of tributyltin and 17β-estradiol in male Chinese loach (Misgurnus anguillicaudatus)
TL;DR: It is demonstrated that tributyltin does not induce the synthesis of Vtg in male Chinese loach and that TBT could significantly inhibit Vtg production induced by E2, after exposure to binary mixtures of E2 and TBT for 14 days.
Journal ArticleDOI
Occurrence and Concentrations of Estrogenic Phenolic Compounds in Surface Waters of Rivers Flowing into Masan Bay, Korea
TL;DR: The concentrations of phenolic compounds observed in these river waters were 1-2 orders of magnitude lower than the reported acute toxicity levels (hundreds of micrograms per liter), however, they were only slightly higher than the chronic toxicity levels.
Dissertation
Analyse par spectrométrie de masse d’hormones stéroïdiennes dans les eaux usées et abattement par oxydation chimique
TL;DR: In this article, new analytical methods were developed for the detection and quantification of steroid hormones in surface and waste waters, based on a novel sample introduction method, the laser diode thermal desorption with an atmospheric chemical ionization source, the LDTD-APCI, coupled with tandem mass spectrometry.
References
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Journal ArticleDOI
The nuclear receptor superfamily: the second decade.
David J. Mangelsdorf,Carl S. Thummel,Miguel Beato,Peter Herrlich,Günther Schütz,Kazuhiko Umesono,Bruce Blumberg,Philippe Kastner,Manuel Mark,Pierre Chambon,Ronald M. Evans +10 more
TL;DR: This research presents a new probabilistic procedure called ‘spot-spot analysis’ to characterize the response of the immune system to the presence of E.coli.
Journal ArticleDOI
Cloning of a novel receptor expressed in rat prostate and ovary.
TL;DR: It is concluded that clone 29 cDNA encodes a novel rat ER, which is suggested be named rat ERbeta to distinguish it from the previously cloned ER (ERalpha) from rat uterus.
Journal ArticleDOI
Developmental effects of endocrine-disrupting chemicals in wildlife and humans.
TL;DR: Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.
Journal ArticleDOI
The RXR heterodimers and orphan receptors
TL;DR: The historical links between the steroid and nonsteroid receptor signaling systems are established, the explosive development of the retinoid X receptor (RXR) heterodimer and orphan receptor family is charted, the impact of these discoveries on the authors' understanding of the mechanisms of hormonal signaling is explained, and emerging issues and implications are presented.
Journal ArticleDOI
Evidence for decreasing quality of semen during past 50 years.
TL;DR: There has been a genuine decline in semen quality over the past 50 years, and as male fertility is to some extent correlated with sperm count the results may reflect an overall reduction in male fertility.