Journal ArticleDOI
Endogenously produced 5,6-dihydroxytryptamine may mediate the neurotoxic effects of para-chloroamphetamine.
TLDR
It is hypothesized that the formation of 5,6-DHT, perhaps from endogenous 5-HT, may mediate the toxic effects of PCA, MA and other amphetamine-related drugs on serotonergic neurons and on a subpopulation of cortical neurons.About:
This article is published in Brain Research.The article was published on 1987-09-01. It has received 60 citations till now. The article focuses on the topics: Serotonergic & para-Chloroamphetamine.read more
Citations
More filters
Journal ArticleDOI
Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain
TL;DR: Investigation of chronic pain parenchymal administration of the neurotrophins brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) or NGF could prevent the severe degenerative loss of serotonergic axons normally caused by the selective 5-HT neurotoxin p-chloroamphetamine (PCA).
Journal ArticleDOI
Memory impairment in abstinent MDMA ("Ecstasy") users
TL;DR: The extent of memory impairment correlates with the degree of MDMA exposure and the reduction in brain 5-HT, as indexed by CSF 5-HIAA.
Journal ArticleDOI
(+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates.
George A. Ricaurte,Lysia S. Forno,Mary Ann Wilson,Louis E. DeLanney,Ian Irwin,Mark E. Molliver,J. William Langston +6 more
TL;DR: Results indicate that MDMA is a selective serotonergic neurotoxin in nonhuman primates and that humans using this drug may be at risk for incurring central Serotonergic neuronal damage.
Journal ArticleDOI
Cognitive performance in (+/-) 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users: a controlled study
TL;DR: The present CSF data provide further evidence that MDMA is neurotoxic to brain 5-HT neurons in humans, and the behavioral data suggest that brain5-HT injury is associated with subtle, but significant, cognitive deficits.
Journal Article
Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction.
Seiden Ls,Sabol Ke +1 more
TL;DR: The hydroxy radical and DA mediation theories are both well supported by the data reviewed and accounts for the fact that amphetamine-analog neurotoxicity is selectively toxic to the DA and/or 5-HT systems of the brain.
References
More filters
Book
Statistical Principles in Experimental Design
TL;DR: In this article, the authors introduce the principles of estimation and inference: means and variance, means and variations, and means and variance of estimators and inferors, and the analysis of factorial experiments having repeated measures on the same element.
Journal ArticleDOI
Statistical Principles in Experimental Design
TL;DR: This chapter discusses design and analysis of single-Factor Experiments: Completely Randomized Design and Factorial Experiments in which Some of the Interactions are Confounded.
Journal ArticleDOI
Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system.
Robert P. Fink,Lennart Heimer +1 more
TL;DR: The original, non-suppressive Natua method for impregenation of terminal degeneration has been modified by the introduction of a potassium permanganate-uranyl nitrate sequence, resulting in a selective impregnation of degenarated axons inclusive of their synaptic thickenings.