Journal ArticleDOI
Enhanced camptothecin production by ethanol addition in the suspension culture of the endophyte, Fusarium solani
TLDR
The study indicates a dual role of ethanol, presumably as an elicitor and also as a carbon/energy source, leading to enhanced biomass and camptothecin production.About:
This article is published in Bioresource Technology.The article was published on 2015-07-01. It has received 48 citations till now. The article focuses on the topics: Fusarium solani & Energy source.read more
Citations
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Secondary metabolism of pharmaceuticals in the plant in vitro cultures: strategies, approaches, and limitations to achieving higher yield
Tasiu Isah,Shahid Umar,Abdul Mujib,Maheshwar Prasad Sharma,P. E. Rajasekharan,Nadia Zafar,Arajmand Frukh +6 more
TL;DR: The effort has shifted towards optimizing culture conditions for high-value pharmaceuticals production through the application of cell line selection, elicitation, precursor feeding, two-phase co-culture among cell, tissue, and organ culture approaches.
Journal ArticleDOI
Endophytes as in vitro production platforms of high value plant secondary metabolites.
TL;DR: Various bioprocess optimization strategies that have been applied to sustain and enhance the product yield from the endophytes have been described in detail and techniques like mixed fermentation/co-cultivation and use of epigenetic modifiers have also been discussed as potential strategies to activate cryptic gene clusters in endophytic fungi, thereby aiding in novel metabolite discovery and overcoming the limitations associated with axenic culture.
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Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta
TL;DR: Following the path traced by the blockbuster drug taxol, an increasing number of valuable compounds originally characterized as secondary metabolites of plant species belonging to the Spermatophyta have been reported as fermentation products of endophytic fungal strains.
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Enhanced camptothecin production induced by elicitors in the cell suspension cultures of Ophiorrhiza mungos Linn.
S. Deepthi,K. Satheeshkumar +1 more
TL;DR: The results obtained in the present investigation suggest the use of elicitation as a promising alternative method to increase CPT production and cell growth in the cell suspension cultures of O. mungos.
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Characterization and antitumor activity of camptothecin from endophytic fungus Fusarium solani isolated from Camptotheca acuminate.
TL;DR: The endophytic fungi from camptotheca trees are a reliable source for natural anticancer compounds and the fungal CPT exhibited effective activity at inhibiting cell growth and inducing apoptosis on Vero cells.
References
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Endophytic fungi for producing bioactive compounds originally from their host plants
TL;DR: This chapter mainly reviewed the research progress on the endophytic fungi for producing plant-derived bioactive compounds such as paclitaxel, podophyllotoxin, camptothecine, vinblastine, hypericin and diosgenin etc.
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Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania.
TL;DR: For these parasites, camptothecin is an important lead for much-needed new chemotherapy, as well as a valuable tool for studying topoisomerase I activity.
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Present trends and future strategy in chemotherapy of malaria.
TL;DR: The well known biochemical target sites such as folate metabolism, pyrimidine metabolism and polyamines for the designing of antimalarial drugs, and the newly discovered biochemical target Sites, alpha-tublin and DNA topoisomerases have been highlighted.
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Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin
Touseef Amna,Satish Chander Puri,Vijeshwar Verma,Jai P Sharma,Rajinder Kumar Khajuria,Javed Musarrat,Michael Spiteller,Gulam Nabi Qazi +7 more
TL;DR: One of the isolates from the inner bark tissue of the N. foetida plant growing in the Jammu region of J&K state, India, was found to produce detectable quantities of camptothecin and its derivatives when grown in a semi-synthetic liquid medium.
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Effect of artificial reconstitution of the interaction between the plant Camptotheca acuminata and the fungal endophyte Fusarium solani on camptothecin biosynthesis.
TL;DR: The present results reveal the causes of decreased production of 1 on subculturing, which could not be reversed by host-endophyte reassociation, and a cross-species biosynthetic pathway is proposed where the endophyte utilizes indigenous G10H (geraniol 10-hydroxylase), SLS (secologanin synthase) to biosynthesize precursors of 1.