Journal ArticleDOI
Enhancement of dissolution rate of poorly-soluble active ingredients by supercritical fluid processes. Part I: Micronization of neat particles.
M. Perrut,J. Jung,F. Leboeuf +2 more
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TLDR
Experimental results confirm that dissolution rates do not only depend on the surface area and particle size of the processed powder, but are greatly affected by other physico-chemical characteristics such as crystal morphology and wettability that may reduce the benefit of micronization.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2005-01-06. It has received 217 citations till now. The article focuses on the topics: Supercritical fluid & Micronization.read more
Citations
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Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates.
TL;DR: The concept and theory of crystal engineering is covered and the potential benefits, disadvantages and methods of preparation of co-crystals, metastable polymorphs, high-energy amorphous forms and ultrafine particles are discussed.
Journal ArticleDOI
Biodegradable particle formation for drug and gene delivery using supercritical fluid and dense gas.
TL;DR: This review is a comprehensive review specifically focused on the formation of biodegradable particles for drug and gene delivery system using supercritical fluid and dense gas.
Journal ArticleDOI
Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals - A comprehensive review.
Luis Padrela,Miguel Rodrigues,Andreia Duarte,Ana M.A. Dias,Mara E.M. Braga,Hermínio C. de Sousa +5 more
TL;DR: A comprehensive state‐of‐the‐art review on scCO2‐based processes focused on the formation and on the control of the physicochemical, structural and morphological properties of amorphous/crystalline pure drug nanoparticles.
Journal ArticleDOI
Micronization of atorvastatin calcium by antisolvent precipitation process.
TL;DR: In the dissolution tests, the amorphous AC ultrafine powder exhibited enhanced dissolution property when compared to the raw material.
Journal ArticleDOI
Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential
TL;DR: The study shows that phospholipid‐based phytosome is a promising and viable strategy for improving the delivery of apigenin and similar phytoconstituents with low aqueous solubility.
References
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Book
Remington's pharmaceutical sciences
TL;DR: The 17th edition of Remington's pharmaceutical sciences is organized as its immediate predecessors, adhering to the concept of division into 9 parts, each subdivided into several chapters as mentioned in this paper.
Remington's pharmaceutical sciences
TL;DR: The 17th edition of Remington's pharmaceutical sciences is organized as its immediate predecessors, adhering to the concept of division into 9 parts, each subdivided into several chapters, with an actual physical increase of fewer that 100 pages.
Journal ArticleDOI
Particle design using supercritical fluids: Literature and patent survey
Jennifer Jung,Michel Perrut +1 more
TL;DR: A survey of published knowledge classified according to the different concepts currently used to manufacture particles, microspheres or microcapsules, liposomes or other dispersed materials (like microfibers) is presented in this article.
Journal ArticleDOI
Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985).
RA Prentis,Y Lis,SR Walker +2 more
TL;DR: The majority of first drug evaluations in human volunteers were carried out in the UK, in contrast to evaluation of new medicines in patients, where 42.9% were first tested outside the UK.
Journal ArticleDOI
Cyclodextrins--enabling excipients: their present and future use in pharmaceuticals.
TL;DR: The current and future regulatory process facing excipients is summarized, and the current regulatory status of the CDs in Japan, the United States, and Europe is presented.
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Particle design using supercritical fluids: Literature and patent survey
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