Entrainment of rat circadian rhythms by daily injection of melatonin depends upon the hypothalamic suprachiasmatic nuclei
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The data suggest that the behavioral effects of melatonin, like those on reproduction in seasonally breeding mammals, depend upon an intact circadian system and the SCN.About:
This article is published in Physiology & Behavior.The article was published on 1986-01-01 and is currently open access. It has received 233 citations till now. The article focuses on the topics: Light effects on circadian rhythm & Melatonin.read more
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Hypothalamic regulation of sleep and circadian rhythms
TL;DR: These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake–sleep cycles into the optimal pattern for survival.
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Melatonin receptors: Localization, molecular pharmacology and physiological significance
TL;DR: Evidence indicates that melatonin acts to inhibit intracellular cyclic AMP through a G-protein coupled mechanism, demonstrating that this is a common signal transduction pathway for many melatonin receptors.
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Cellular Mechanisms of Melatonin Action
TL;DR: Molecular mechanisms of the melatonin effects are not clear but may involve at least two parallel transduction pathways, one inhibiting adenylyl cyclase and the other regulating phospholipide metabolism and [Ca2+]i.
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Melatonin as a chronobiotic.
Josephine Arendt,Debra J. Skene +1 more
TL;DR: Successful use of melatonin's chronobiotic properties has been reported in other sleep disorders associated with abnormal timing of the circadian system: jetlag, shiftwork, delayed sleep phase syndrome, some sleep problems of the elderly.
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The Timed Infusion Paradigm for Melatonin Delivery - What has it Taught Us About the Melatonin Signal, its Reception, and the Photoperiodic Control of Seasonal Responses
TL;DR: It is the collective view that the TIP has played, and will continue to play, a pivotal role in elucidation of the function of MEL in the photoperiodic control of seasonal mammalian responses and that the duration of the MEL signal is the critical parameter of the nocturnal secretion profile of the hormone for the phot operable control of several seasonally adaptive responses in mammalian species as diverse as hamsters and sheep.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat.
TL;DR: The purpose of the present study was to reinvestigate the role of the central retinal projections in neuroendocrine regulation and find that lesions in the suprachiasmatic region of the hypothalamus abolish the constant estrous response to light in the female rat.
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Circadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are Eliminated by Hypothalamic Lesions
TL;DR: Bilateral electrolytic lesions in the suprachiasmatic nuclei permanently eliminated nocturnal and circadian rhythms in drinking behavior and locomotor activity of albino rats.
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Persistence of circadian rhythmicity in a mammalian hypothalamic "island" containing the suprachiasmatic nucleus
TL;DR: Simultaneous recording from two extracellular electrodes indicated neural activity at two sites in the brain, one of which is in or near the suprachiasmatic nucleus and the other in one of many other brain locations, which indicated clear circadian rhythmicity of spontaneous neural activity.