Journal ArticleDOI
Enzymic synthesis of L-ascorbic acid from synthetic and biological D-glucurono-1,4-lactone conjugates.
TLDR
It has been indicated that the enhanced synthesis of l -ascorbic acid after administration of various drugs and toxic chemical compounds is due to the induced formation of this endogenous substrate.About:
This article is published in Analytical Biochemistry.The article was published on 1970-11-01. It has received 10 citations till now. The article focuses on the topics: Ascorbic acid & Oxime.read more
Citations
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Journal ArticleDOI
Evolution and the biosynthesis of ascorbic acid
TL;DR: The ability to synthesize ascorbic acid is absent in the insects, invertebrates, and fishes and a similar transition in the biosynthetic ability was observed in the branched evolution of the birds.
Journal ArticleDOI
Synthesis and some major functions of vitamin C in animals.
TL;DR: Using the in vitro method, the ascorbic acid synthesizing abilities of different species of animals in the phylogenetic tree are examined, and the results are given below.
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Role of L-ascorbic acid on detoxification of histamine
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Is L-gulonolactone-oxidase the only enzyme missing in animals subject to scurvy?
TL;DR: It is shown that highly purified L-glulonolactone oxidase catalyzes the conversion of the oxime and semicarbazone of D-glucuronolact one to the corresponding ascorbic acid derivative and there is no need to propose a second pathway to ascorBic acid, nor is there evidence for more than the one enzyme defect in scurvy-prone animals.
References
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Journal ArticleDOI
A specific micromethod for the determination of acyl phosphates
TL;DR: In this communication, a method is described which utilizes the reaction of acyl phosphates with hydroxylamine and the acyl part of the acid anhydride is converted into hydroxamic acid.
Journal ArticleDOI
Stimulatory effect of barbital on urinary excretion of L-ascorbic acid and nonconjugated D-glucuronic acid.
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The effect of organic compounds upon vitamin C synthesis in the rat.
TL;DR: The excretion of ascorbic acid by albino rats maintained as previously described was greatly accelerated by a series of compounds, most of them having in common the characteristic of functioning in vivo as depressors of the nervous system.
Journal ArticleDOI
MICROANALYSIS OF GLUCURONIDE GLUCURONIC ACID AS APPLIED TO β-GLUCURONIDASE AND GLUCURONIC ACID STUDIES
William H. Fishman,Sidney Green +1 more
TL;DR: Under special circumstances, both free and conjugated acid can be determined, making possible a number of important applications of the proposed procedure, examples of which are presented.
Journal ArticleDOI
Biological synthesis of L-ascorbic acid in animal tissues: conversion of L-gulonolactone into L-ascorbic acid.
TL;DR: The experiments indicate that the observed activity of mitochondria is probably due to their contamination by microsomes, and the microsomal enzyme concerned in the oxidation of L-gulonolactone to L-ascorbic acid is inhibited by heavy-metal ions and reversibly by p-chloromercuribenzoate, indicating the involvement of some essential thiol groups in the enzyme.
Related Papers (5)
Enzymatic formation of ascorbic acid in rat liver extracts.
Missing Step in Man, Monkey and Guinea Pig required for the Biosynthesis of L-Ascorbic Acid
J. J. Burns,J. J. Burns +1 more