Epidemiology of systemic lupus erythematosus: an update.
George Stojan,Michelle Petri +1 more
TLDR
Sex, race, and ethnicity significantly affect SLE incidence, prevalence, and mortality.Abstract:
Purpose of reviewSystemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease with a significant disease burden across the world among different ethnic, racial, and age groups. The pathophysiological understanding of SLE is constantly evolving and with it, the need for a betterread more
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Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis.
Tiffany Caza,Samar I. Hassen,Michael Kuperman,Shree G. Sharma,Zeljko Dvanajscak,John M. Arthur,Rick D. Edmondson,Aaron J. Storey,Christian Herzog,Daniel J. Kenan,Christopher P. Larsen +10 more
TL;DR: It is proposed that NCAM1 is a target autoantigen in a subset of patients with membranous lupus nephritis, and future studies are needed to determine whether anti-NCAM1 antibody levels correlate with disease activity or response to therapy.
Journal ArticleDOI
Comparative United States autoimmune disease rates for 2010-2016 by sex, geographic region, and race.
Melissa H. Roberts,Esther Erdei +1 more
TL;DR: Substantial AID heterogeneity exists by race and by geographic area, and an important research area is further exploring factors related to heterogeneity such as potential interactions between genetic susceptibility and environmental factors.
Journal ArticleDOI
Alteration in gut microbiota is associated with dysregulation of cytokines and glucocorticoid therapy in systemic lupus erythematosus.
Mengchen Guo,Huixia Wang,Sixie Xu,Yaoyao Zhuang,Jingang An,Chuan Su,Yankai Xia,Jingyun Chen,Zhenjiang Zech Xu,Qisha Liu,Jianwei Wang,Zhou Dan,Kun Chen,Xiaoting Luan,Zhi Liu,Kangjian Liu,Faming Zhang,Yumin Xia,Xingyin Liu +18 more
TL;DR: The diversity and structure of the microbial community in SLE+G patients were significantly changed compared to that of SLE-G patients, whereas the gut microbial community of the Sle+G group showed a similarity with the HC group, which implicate that the shift in the gut microbiome could represent a return to homeostasis.
Journal ArticleDOI
Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review.
TL;DR: It was observed that a low-calorie and low-protein diet with high contents of fiber, polyunsaturated fatty acids, vitamins, minerals and polyphenols contain sufficient potential macronutrients and micronutrient to regulate the activity of the overall disease by modulating the inflammation and immune functions of SLE.
Journal ArticleDOI
Risk of systemic lupus erythematosus in patients with idiopathic thrombocytopenic purpura: a population-based cohort study.
TL;DR: It is demonstrated that patients with ITP have a higher risk of SLE than the age-matched and sex-matched population and should be monitored for incidental lupus.
References
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Journal ArticleDOI
The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies.
Frances Rees,Frances Rees,Michael Doherty,Matthew J. Grainge,Peter Lanyon,Peter Lanyon,Weiya Zhang +6 more
TL;DR: There are worldwide differences in the incidence and prevalence of SLE that vary with sex, age, ethnicity and time and further study of genetic and environmental risk factors may explain the reasons for these differences.
Journal ArticleDOI
Population-Based Incidence and Prevalence of Systemic Lupus Erythematosus: The Michigan Lupus Epidemiology and Surveillance Program
Emily C. Somers,Wendy Marder,Patricia Cagnoli,Emily E. Lewis,Peter DeGuire,Caroline Gordon,Charles G. Helmick,Lu Wang,Jeffrey J. Wing,J. Patricia Dhar,James C. C. Leisen,Diane Shaltis,W. Joseph McCune +12 more
TL;DR: There were substantial racial disparities in the burden of SLE, with black patients experiencing earlier age at diagnosis, >2-fold increases in SLE incidence and prevalence, and increased proportions of renal disease and progression to ESRD as compared to white patients.
Journal ArticleDOI
The incidence and prevalence of systemic lupus erythematosus, 2002-2004: The Georgia Lupus Registry.
S. Sam Lim,A. Rana Bayakly,Charles G. Helmick,Caroline Gordon,Kirk A. Easley,Cristina Drenkard +5 more
TL;DR: The Georgia Lupus Registry is a population‐based registry designed to improve the ability to estimate the incidence and prevalence of systemic lupus erythematosus in a large population.
Journal ArticleDOI
The incidence and prevalence of systemic lupus erythematosus in the UK, 1999–2012
TL;DR: The incidence of SLE has been declining but the prevalence has been increasing in the UK in recent years, and people of Black Caribbean ethnicity had the highest incidence and prevalence.
Journal ArticleDOI
Overall and cause-specific mortality in systemic lupus erythematosus: an updated meta-analysis:
TL;DR: Patients with SLE had higher rates of death from all causes, regardless of sex, ethnicity, renal disease, CVD or infection, however, the risk of death due to malignancy was not increased.
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