ERS technical standard on bronchial challenge testing: General considerations and performance of methacholine challenge tests
Allan L. Coates,J. Wanger,Donald W. Cockcroft,Bruce H. Culver,Kai-Håkon Carlsen,Zuzana Diamant,Zuzana Diamant,Gail M. Gauvreau,Graham L. Hall,Teal S. Hallstrand,Ildiko Horvath,Frans H.C. de Jongh,Guy Joos,David A. Kaminsky,Beth L. Laube,Joerg D. Leuppi,Peter J. Sterk +16 more
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This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test to include notable changes from prior recommendations in order to accommodate newer delivery devices.Abstract:
This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test. There are notable changes from prior recommendations in order to accommodate newer delivery devices. Rather than basing the test result upon a methacholine concentration (provocative concentration (PC20) causing a 20% fall in forced expiratory volume in 1 s (FEV1)), the new recommendations base the result upon the delivered dose of methacholine causing a 20% fall in FEV1 (provocative dose (PD20)). This end-point allows comparable results from different devices or protocols, thus any suitable nebuliser or dosimeter may be used, so long as the delivery characteristics are known. Inhalation may be by tidal breathing using a breath-actuated or continuous nebuliser for 1 min (or more), or by a dosimeter with a suitable breath count. Tests requiring maximal inhalations to total lung capacity are not recommended because the bronchoprotective effect of a deep breath reduces the sensitivity of the test.read more
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Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement.
Brian L. Graham,Irene Steenbruggen,Martin R. Miller,Igor Barjaktarevic,Brendan G Cooper,Graham L. Hall,Teal S. Hallstrand,David A. Kaminsky,Kevin McCarthy,Meredith C. McCormack,Cristine E Oropez,Margaret Rosenfeld,Sanja Stanojevic,Maureen P. Swanney,Bruce Thompson +14 more
TL;DR: Standards and consensus recommendations are presented for manufacturers, clinicians, operators, and researchers with the aims of increasing the accuracy, precision, and quality of spirometric measurements and improving the patient experience.
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Double-blind clinical trial of calf lung surfactant extract for the prevention of hyaline membrane disease in extremely premature infants
TL;DR: Calf lung surfactant extract instillation at birth appears to be an effective material and method of preventing hyaline membrane disease in extremely premature infants.
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High prevalence of exercise-induced laryngeal obstruction in athletes with respiratory symptoms
TL;DR: In this article, the prevalence of exercise induced laryngeal obstruction (EILO) in an unselected cohort of athletes was evaluated and the presence of inspiratory symptoms did not differentiate athletes with and without EILO.
Journal ArticleDOI
ERS technical standard on bronchial challenge testing: Pathophysiology and methodology of indirect airway challenge testing
Teal S. Hallstrand,Joerg D. Leuppi,Guy Joos,Graham L. Hall,Kai-Håkon Carlsen,David A. Kaminsky,Allan L. Coates,Donald W. Cockcroft,Bruce H. Culver,Zuzana Diamant,Zuzana Diamant,Gail M. Gauvreau,Ildiko Horvath,Frans H.C. de Jongh,Beth L. Laube,Peter J. Sterk,J. Wanger +16 more
TL;DR: An updated description of the pathophysiology and the methods to conduct indirect challenge tests for asthma and recommendations for the conduct and interpretation of hyperpnoea challenge tests such as dry air exercise challenge and eucapnic voluntary hyperPNoea that provide a single strong stimulus for airway narrowing.
Journal ArticleDOI
European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years.
Erol A. Gaillard,Erol A. Gaillard,Claudia E. Kuehni,Claudia E. Kuehni,Steve Turner,Myrofora Goutaki,Myrofora Goutaki,Karl Holden,Carmen C.M. de Jong,Christiane Lex,David Lo,David Lo,Jane S. Lucas,Jane S. Lucas,Fabio Midulla,Rebeca Mozun,Giorgio Piacentini,David Rigau,Bart L. Rottier,Mike Thomas,Thomy Tonia,Jakob Usemann,Ozge Yilmaz,Angela Zacharasiewicz,Alexander Moeller +24 more
TL;DR: In this article, a Task Force (TF) supported by the European Respiratory Society has developed these evidence-based clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years using nine PICO (Population, Intervention, Comparator and Outcome) questions.
References
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