Estrogenic Activity of Coffee Constituents.
TLDR
In this paper, the constituents of coffee with estrogenic activity are summarized by a comprehensive literature search, and their mechanisms of action for their physiological effects are discussed at the molecular and cellular levels.Abstract:
Here, the constituents of coffee with estrogenic activity are summarized by a comprehensive literature search, and their mechanisms of action for their physiological effects are discussed at the molecular and cellular levels. The estrogenic activity of coffee constituents, such as acids, caramelized products, carbohydrates, lignin, minerals, nitrogenous compounds, oil (lipids), and others, such as volatile compounds, was first evaluated by activity assays, such as animal tests, cell assay, ligand-binding assay, protein assay, reporter-gene assay, transcription assay, and yeast two-hybrid assay. Second, the health benefits associated with the estrogenic coffee constituents, such as bone protection, cancer treatment/prevention, cardioprotection, neuroprotection, and the improvement of menopausal syndromes, were summarized, including their potential therapeutic/clinical applications. Inconsistent results regarding mixed estrogenic/anti-estrogenic/non-estrogenic or biphasic activity, and unbeneficial effects associated with the constituents, such as endocrine disruption, increase the complexity of the effects of estrogenic coffee constituents. However, as the increase of the knowledge about estrogenic cell signaling, such as the types of specific signaling pathways, selective modulations of cell signaling, signal crosstalk, and intercellular/intracellular networks, pathway-based assessment will become a more realistic means in the future to more reliably evaluate the beneficial applications of estrogenic coffee constituents.read more
Citations
More filters
반도체 공정 overview
TL;DR: The study of distributed systems which bring to life the vision of ubiquitous computing systems, also known as ambient intelligence, is concentrated on in this work.
Journal ArticleDOI
Nutritional implications of ginger: chemistry, biological activities and signaling pathways.
TL;DR: The molecular mechanisms of estrogen actions induced by ginger constituents and related applications, such as the chemoprevention of cancers, and the improvement of menopausal syndromes, osteoporosis, endometriosis, prostatic hyperplasia, polycystic ovary syndrome and Alzheimer's disease, were summarized by a comprehensive search of references.
Chlorogenic Acid의 면역보조제 효과
TL;DR: Investigation if chlorogenic acid (CRA), a polyphenolic compound, has an immunoadjuvant activity showed that CRA enhanced the proliferation of those lymphocytes in dose-dependant manner.
Journal ArticleDOI
Effect of Roasting Levels and Drying Process of Coffea canephora on the Quality of Bioactive Compounds and Cytotoxicity
Deborah Bauer,Joel Pimentel de Abreu,Nathállia Araújo Jordão,Jeane Santos da Rosa,Otniel Freitas-Silva,Anderson Junger Teodoro +5 more
TL;DR: Coffee extracts promoted a decrease in cell viability, modulated cell cycle and induced apoptosis in human prostate carcinoma cell line (DU-145), and the level of roasting reduced this property, but the type of drying did not in all cases.
Journal ArticleDOI
Natural and Synthetic Derivatives of Hydroxycinnamic Acid Modulating the Pathological Transformation of Amyloidogenic Proteins.
Vladimir I. Muronetz,K.V. Barinova,S. S. Kudryavtseva,Maria Medvedeva,Aleksandra K. Melnikova,Irina A. Sevostyanova,Pavel I. Semenyuk,Yulia Yu. Stroylova,Yulia Yu. Stroylova,Matej Sova +9 more
TL;DR: The ability of HCA derivatives to preventAmyloid transformation of some amyloidogenic proteins, and their presence not only in food products but also as natural metabolites in human blood and tissues, makes them promising for the prevention and treatment of neurodegenerative diseases of amyloids nature.
References
More filters
반도체 공정 overview
TL;DR: The study of distributed systems which bring to life the vision of ubiquitous computing systems, also known as ambient intelligence, is concentrated on in this work.
Journal ArticleDOI
Estrogen carcinogenesis in breast cancer.
James D. Yager,Nancy E. Davidson +1 more
TL;DR: Insight into the mechanisms of the causation of cancer by estrogen will identify determinants of susceptibility to breast cancer and new targets for prevention and therapeutic intervention.
Journal ArticleDOI
Induced protein degradation: an emerging drug discovery paradigm
Ashton C. Lai,Craig M. Crews +1 more
TL;DR: Induced protein degradation has the potential to reduce systemic drug exposure, the ability to counteract increased target protein expression that often accompanies inhibition of protein function and the potential ability to target proteins that are not currently therapeutically tractable, such as transcription factors, scaffolding and regulatory proteins.
Journal ArticleDOI
Coffee and its Consumption: Benefits and Risks
TL;DR: This review article is an attempt to disseminate general information, health claims, and obviously the risk factors associated with coffee consumption to scientists, allied stakeholders, and certainly readers.
Journal ArticleDOI
Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens.
TL;DR: The phytoestrogens showed a preference to bind to ER-beta, but only genistein showed a much lower activity in the E-Screen (growth induction in breast cancer cells) compared with the luciferase induction in MVLN and HGELN-cells.