EUROGIN 2014 roadmap: Differences in human papillomavirus infection natural history, transmission and human papillomavirus‐related cancer incidence by gender and anatomic site of infection
Anna R. Giuliano,Alan G. Nyitray,Aimée R. Kreimer,Christine M. Pierce Campbell,Marc T. Goodman,Staci L. Sudenga,Joseph Monsonego,Silvia Franceschi +7 more
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In this paper, differences in HPV-related cancer and infection burden by gender and anatomic site are reviewed, with nearly 100% of cervical, 88% of anal, and <50% of lower genital tract and oropharyngeal cancers attributable to HPV.Abstract:
Human papillomaviruses (HPVs) cause cancer at multiple anatomic sites in men and women, including cervical, oropharyngeal, anal, vulvar and vaginal cancers in women and oropharyngeal, anal and penile cancers in men. In this EUROGIN 2014 roadmap, differences in HPV-related cancer and infection burden by gender and anatomic site are reviewed. The proportion of cancers attributable to HPV varies by anatomic site, with nearly 100% of cervical, 88% of anal and <50% of lower genital tract and oropharyngeal cancers attributable to HPV, depending on world region and prevalence of tobacco use. Often, mirroring cancer incidence rates, HPV prevalence and infection natural history varies by gender and anatomic site of infection. Oral HPV infection is rare and significantly differs by gender; yet, HPV-related cancer incidence at this site is several-fold higher than at either the anal canal or the penile epithelium. HPV seroprevalence is significantly higher among women compared to men, likely explaining the differences in age-specific HPV prevalence and incidence patterns observed by gender. Correspondingly, among heterosexual partners, HPV transmission appears higher from women to men. More research is needed to characterize HPV natural history at each anatomic site where HPV causes cancer in men and women, information that is critical to inform the basic science of HPV natural history and the development of future infection and cancer prevention efforts.read more
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Epidemiology of Human Papillomavirus–Positive Head and Neck Squamous Cell Carcinoma
TL;DR: Recent data are reviewed to provide insight into several topics, including incidence trends and projections for HPV-positive HNC; the worldwide HPV-attributable fraction; sex disparities in cancer risk; the epidemiology of oral HPV infection; the latency period between infection and cancer; the potential impact of prophylactic HPV vaccination; and prospects for secondary prevention.
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Cancer and lesbian, gay, bisexual, transgender/transsexual, and queer/questioning (LGBTQ) populations.
Gwendolyn P. Quinn,Julian Sanchez,Steven K. Sutton,Susan T. Vadaparampil,Giang T. Nguyen,B. Lee Green,Peter A. Kanetsky,Matthew B. Schabath +7 more
TL;DR: An overview of the current literature on seven cancer sites that may disproportionately affect lesbian, gay, bisexual, transgender/transsexual, and queer/questioning (LGBTQ) populations is provided.
Journal ArticleDOI
Epidemiology and burden of HPV-related disease.
TL;DR: The latest estimates of the global burden of HPV-related diseases, trends, the attributable fraction by HPV types, and the potential preventative fraction are summarized.
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The natural history of human papillomavirus infection.
TL;DR: Viral load and viral type are the main cofactors for progression from infection to cervical intraepithelial lesions and cancer and the adverse health effects of HPV infections can be largely controlled through vaccination and screening.
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The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review
TL;DR: The productive life cycle of HPV is described and the roles of the viral proteins in HPV replication are discussed, including routes to viral persistence and cancer progression are also discussed.
References
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Yifei Hu,Han-Zhu Qian,Jiangping Sun,Lei Gao,Lu Yin,Xiangwei Li,Dong Xiao,Dongliang Li,Xiaoyun Sun,Yuhua Ruan,Douglas F. Milam,Stephen W. Pan,Yiming Shao,Sten H. Vermund +13 more
TL;DR: HPV anal infections were more common among HIV-infected than uninfected MSM in China, including oncogenic and multiple types, and unprotected oral and receptive anal sex were independently associated with HPV infection.
Journal ArticleDOI
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Zoe R. Edelstein,Joseph J. Carter,Ruchi Garg,Rachel L. Winer,Qinghua Feng,Denise A. Galloway,Laura A. Koutsky +6 more
TL;DR: For each of the α9 HPV types, type-specific seroconversion within 24 months was observed in 36% or less of infected men, which might be related to cigarette smoking and genital site(s) infected.
Journal ArticleDOI
Human papillomavirus infection and abnormal cytology of the anus in HIV-infected and uninfected adolescents.
Anna-Barbara Moscicki,Stephen J. Durako,Jolene Houser,Yong Ma,Debra A. Murphy,Teresa M. Darragh,Sepideh Farhat,Craig M. Wilson +7 more
TL;DR: Strong risk factors for abnormal anal cytology were HIV infection and anal HPV in boys and analHPV and higher number of sexual partners for girls and the results suggest that anus cytology screening should be considered in HIV infected homosexual/bisexual males.
Journal ArticleDOI
Seroepidemiology of Infection with Human Papillomavirus 16, in Men and Women Attending Sexually Transmitted Disease Clinics in the United States
Deborah L Thompson,John M. Douglas,John M. Douglas,Mark Foster,Michael E. Hagensee,Carolyn DiGuiseppi,Anna E Barón,Jennifer E. Cameron,Timothy C Spencer,Jonathan M. Zenilman,C. Kevin Malotte,Gail Bolan,Mary L. Kamb,Thomas A. Peterman +13 more
TL;DR: Sex- and age-related differences in both the seropositivity and seroincidence of HPV-16 antibody persisted after adjustment for behavioral and sociodemographic risk factors, and behavioral risk factors during the preceding 3 months were stronger predictors of theSeroprevalence and seriosexual activity than was lifetime sexual behavior.
Journal ArticleDOI
Prevalence, genotype diversity and determinants of anal HPV infection in HIV-uninfected men having sex with men.
Maria Gabriella Donà,Guido Palamara,Aldo Di Carlo,Alessandra Latini,Amina Vocaturo,Maria Benevolo,Fulvia Pimpinelli,Amalia Giglio,Domenico Moretto,Giampaolo Impara,Massimo Giuliani +10 more
TL;DR: The present findings highlight the need to create a more significant awareness about the risk of anal HPV infection among HIV-uninfected MSM and warrant the investigation of possible anal intraepithelial lesions, particularly in view of the increasing anal cancer incidence in high-risk populations.
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