EUROGIN 2014 roadmap: Differences in human papillomavirus infection natural history, transmission and human papillomavirus‐related cancer incidence by gender and anatomic site of infection
Anna R. Giuliano,Alan G. Nyitray,Aimée R. Kreimer,Christine M. Pierce Campbell,Marc T. Goodman,Staci L. Sudenga,Joseph Monsonego,Silvia Franceschi +7 more
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TLDR
In this paper, differences in HPV-related cancer and infection burden by gender and anatomic site are reviewed, with nearly 100% of cervical, 88% of anal, and <50% of lower genital tract and oropharyngeal cancers attributable to HPV.Abstract:
Human papillomaviruses (HPVs) cause cancer at multiple anatomic sites in men and women, including cervical, oropharyngeal, anal, vulvar and vaginal cancers in women and oropharyngeal, anal and penile cancers in men. In this EUROGIN 2014 roadmap, differences in HPV-related cancer and infection burden by gender and anatomic site are reviewed. The proportion of cancers attributable to HPV varies by anatomic site, with nearly 100% of cervical, 88% of anal and <50% of lower genital tract and oropharyngeal cancers attributable to HPV, depending on world region and prevalence of tobacco use. Often, mirroring cancer incidence rates, HPV prevalence and infection natural history varies by gender and anatomic site of infection. Oral HPV infection is rare and significantly differs by gender; yet, HPV-related cancer incidence at this site is several-fold higher than at either the anal canal or the penile epithelium. HPV seroprevalence is significantly higher among women compared to men, likely explaining the differences in age-specific HPV prevalence and incidence patterns observed by gender. Correspondingly, among heterosexual partners, HPV transmission appears higher from women to men. More research is needed to characterize HPV natural history at each anatomic site where HPV causes cancer in men and women, information that is critical to inform the basic science of HPV natural history and the development of future infection and cancer prevention efforts.read more
Citations
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Giving Boys a Shot: The HPV Vaccine’s Portrayal in Canadian Newspapers
TL;DR: Canadian newspaper articles investigated what information about the HPV vaccine was relayed to the public, and how this content was portrayed following the 2012 male HPV vaccine recommendation, finding that article tone toward male vaccination became progressively more positive over time.
Journal ArticleDOI
Prevalence of human papillomavirus in tonsil brushings and gargles in cancer-free patients: The SPLIT study
Jean-Damien Combes,Véronique Dalstein,Véronique Dalstein,Tarik Gheit,Gary M. Clifford,Massimo Tommasino,Christine Clavel,Christine Clavel,Jean Lacau St Guily,Silvia Franceschi +9 more
TL;DR: HPV infection is infrequent in tonsil brushings of cancer-free children and adults, and low agreement in paired tonsil Brushings and gargles suggests that gargle is not representative of HPV prevalence in the tonsil.
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Human Papillomavirus Genotype Replacement: Still Too Early to Tell?
TL;DR: A transmission model in which a vaccine type and an NVT compete through infection-induced cross-immunity is constructed, finding that vaccine effectiveness for NVTs is inadequate for indicating type replacement.
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HPV infection and bacterial microbiota in breast milk and infant oral mucosa
Heidi Tuominen,Samuli Rautava,Maria Carmen Collado,Stina Syrjänen,Stina Syrjänen,Jaana Rautava,Jaana Rautava +6 more
TL;DR: HPV infection is associated with distinct oral bacterial microbiota composition in infants, and the direction of causality underlying the phenomenon remains unclear.
Journal ArticleDOI
Comprehensive pharmacogenomic profiling of human papillomavirus-positive and -negative squamous cell carcinoma identifies sensitivity to aurora kinase inhibition in KMT2D mutants.
Nene N. Kalu,Tuhina Mazumdar,Shaohua Peng,Pan Tong,Li Shen,Jing Wang,Upasana Banerjee,Jeffrey N. Myers,Curtis R. Pickering,David Brunell,Clifford Stephan,Faye M. Johnson +11 more
TL;DR: This is the first published study to demonstrate that mutations in KMT2D, which are common in many cancers, correlate with drug sensitivity in two independent datasets, and is shown to be more sensitive to Aurora kinase inhibitors than were cells without mutations.
References
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Journal ArticleDOI
Global burden of cancers attributable to infections in 2008: a review and synthetic analysis
Catherine de Martel,Jacques Ferlay,Silvia Franceschi,Jérôme Vignat,Freddie Bray,David Forman,Martyn Plummer +6 more
TL;DR: Application of existing public health methods for infection prevention, such as vaccination, safer injection practice, or antimicrobial treatments, could have a substantial effect on the future burden of cancer worldwide.
Journal ArticleDOI
Prevalence of HPV Infection Among Females in the United States
Eileen F. Dunne,Elizabeth R. Unger,Maya R. Sternberg,Geraldine M. McQuillan,David C. Swan,Sonya Patel,Lauri E. Markowitz +6 more
TL;DR: The data indicate that the burden of prevalent HPV infection among females was greater than previous estimates and was highest among those aged 20 to 24 years, however, the prevalence of HPV vaccine types was relatively low.
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Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis.
Silvia de Sanjosé,Mireia Diaz,Xavier Castellsagué,Gary M. Clifford,Laia Bruni,Nubia Muñoz,F. Xavier Bosch +6 more
TL;DR: The HPV types most commonly detected are similar to those most commonly described in pre-neoplastic and cancer cases, although the relative contribution of HPV16 and HPV18 is substantially lower in cytologically normal women.
Journal ArticleDOI
Prevalence of oral HPV infection in the United States, 2009-2010.
Maura L. Gillison,Tatevik Broutian,Robert K. L. Pickard,Zhen-yue Tong,Weihong Xiao,Lisa Kahle,Barry I. Graubard,Anil K. Chaturvedi +7 more
TL;DR: Among men and women aged 14 to 69 years in the United States, the overall prevalence of Oral HPV infection was 6.9%, and the prevalence was higher among men than among women, and associations with age, sex, number of sexual partners, and current number of cigarettes smoked per day were independently associated with oral HPV infection in multivariable models.
Journal ArticleDOI
Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis
Dorothy A Machalek,Mary Poynten,Fengyi Jin,Christopher K Fairley,Annabelle Farnsworth,Suzanne M. Garland,Suzanne M. Garland,Suzanne M. Garland,Richard J. Hillman,Richard J. Hillman,Kathy Petoumenos,Jennifer M. Roberts,Sepehr N. Tabrizi,Sepehr N. Tabrizi,Sepehr N. Tabrizi,David J Templeton,David J Templeton,Andrew E. Grulich +17 more
TL;DR: In this paper, the authors search PubMed, OVID Medline, and Embase for all studies published before Nov 1, 2011, that reported prevalence and incidence of anal HPV detection, intraepithelial neoplasia (AIN), and anal cancer in MSM.
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