Journal ArticleDOI
Evaluating the Loudness of Phantom Auditory Perception (Tinnitus) in Rats
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TLDR
The animal model of tinnitus is extended and evidence that the loudness of phantom auditory perception is expressed through observable behavior, can be evaluated, and its changes detected is provided.Abstract:
Using our behavioral paradigm for evaluating tinnitus, the loudness of salicylate-induced tinnitus was evaluated in 144 rats by comparing their behavioral responses induced by different doses of salicylate to those induced by different intensities of a continuous reference tone mimicking tinnitus. Group differences in resistance to extinction were linearly related to salicylate dose and, at moderate intensities, to the reference tone as well. Comparison of regression equations for salicylate versus tone effects permitted estimation of the loudness of salicylate-induced tinnitus. These results extend the animal model of tinnitus and provide evidence that the loudness of phantom auditory perception is expressed through observable behavior, can be evaluated, and its changes detected.read more
Citations
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Journal ArticleDOI
An integrative model of tinnitus based on a central gain controlling neural sensitivity.
TL;DR: A model highlighting the putative connections between hearing loss and the phantom perception of tinnitus is proposed, suggesting that central hyperactivity in the central auditory system could result from a central gain increase.
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Advances in the neurobiology of hearing disorders: recent developments regarding the basis of tinnitus and hyperacusis
TL;DR: Novel studies confirm the involvement of peripheral de Afferentation for tinnitus and hyperacusis, but suggest that the disorder results from different brain responses to different degrees of deafferentation: while tinnitis may arise as a failure of the brain to adapt to deprived peripheral input, hyperacusIS may result from an 'over-adaptive' increase in response gain.
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Salicylate induced tinnitus: Behavioral measures and neural activity in auditory cortex of awake rats
Guang Yang,Edward Lobarinas,Liyan Zhang,Jeremy G. Turner,Daniel Stolzberg,Richard Salvi,Wei Sun +6 more
TL;DR: Preliminary physiology data suggest that salicylate induced tinnitus is associated with sound evoked hyperactivity in auditory cortex and spontaneous hypoactivity.
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Salicylate-induced abnormal activity in the inferior colliculus of rats.
TL;DR: The evaluated spontaneous activity of 471 units from the external nucleus of the IC revealed that salicylate induces an increase of the spontaneous activity and the emergence of a bursting type of activity longer than 4 spikes, which is consistent with the hypothesis that GABA-mediated disinhibition is involved in the processing of tinnitus-related neuronal activity.
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Tinnitus in hamsters following exposure to intense sound
TL;DR: Hamsters were trained with a conditioned suppression/avoidance procedure to drink in the presence of a broadband noise and/or a tone and to stop drinking in the absence of sound to determine if they behaved as if they perceived a sound when no external sound was present, and the results suggest that the positive scores on the tinnitus test were not due to hearing loss.
References
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Journal ArticleDOI
Phantom auditory perception (tinnitus): mechanisms of generation and perception
TL;DR: Existing theories and their extrapolation are presented, together with some new potential mechanisms of tinnitus generation, encompassing the involvement of calcium and calcium channels in cochlear function, with implications for malfunction and aging of the auditory and vestibular systems.
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Auditory sensitivity of the albino rat.
Jack B. Kelly,Bruce Masterton +1 more
TL;DR: The auditory sensitivity of the (Sprague-Dawley strain) albino rat was determined by the conditioned suppression technique and there was no evidence for a highly specialized tuning of the audiogram to tones in the 30-40 kHz region.
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Phantom auditory sensation in rats: an animal model for tinnitus.
TL;DR: In this article, the authors measured tinnitus induced by sodium salicylate injections and found that resistance to extinction was profound when injections started before training, but minimal when initiated after training.
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Mechanisms of salicylate ototoxicity.
TL;DR: Results of single unit recordings suggest parallels between salicylate intoxication and noise trauma, which are discussed with regard to potential mechanisms of tinnitus generation.
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Effects of salicylate on shape, electromotility and membrane characteristics of isolated outer hair cells from guinea pig cochlea.
TL;DR: The changes in shape and electromotility that the authors observe in vitro may impair cochlear partition movements in vivo and could account, at least in part, for the salicylate-induced hearing loss and effects on otoacoustic emissions.