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Journal ArticleDOI

Exploring natural compounds for the management of non-small cell lung cancer

TLDR
A growing incidence of drug resistance and tumour proliferation in non-small cell lung cancer escalates the urge for potential lead molecules, and the plant-derived natural compounds have played a role in the development of these molecules.
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This article is published in Natural Product Research.The article was published on 2020-07-29. It has received 1 citations till now. The article focuses on the topics: Lung cancer.

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Natural products: Potential targets of TME related long non-coding RNAs in lung cancer

TL;DR: In this article, a combination of TME and lung CSCs, lncRNAs and enrichment and stemness maintenance were identified as potential therapeutic targets, aiming to develop natural product-based therapeutics to treat metastatic and drug-resistant lung cancers.
References
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Journal ArticleDOI

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

TL;DR: A status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions.
Journal ArticleDOI

Natural product and natural product derived drugs in clinical trials

TL;DR: The next few years will be critical for NP-driven lead discovery, and a concerted effort is required to identify new biologically active pharmacophores and to progress these and existing compounds through pre-clinical drug development into clinical trials.
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A Comprehensive Docking and MM/GBSA Rescoring Study of Ligand Recognition upon Binding Antithrombin

TL;DR: The results have demonstrated that it is very important to keep a few top poses for rescoring, if the binding is non-specific or the binding mode is not well determined by the docking calculation.
Journal ArticleDOI

Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction.

TL;DR: Down-regulation of c-Myc and cyclin D1 expression, the two important effectors of the Wnt/β-catenin signaling, is confirmed by treating HCT116 cells with BC21, a new and modifiable potential anticancer candidate that targets β- catenin/Tcf-4 interaction.
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Discovery of small molecule inhibitors of the Wnt/β-catenin signaling pathway by targeting β-catenin/Tcf4 interactions.

TL;DR: This paper reviews the currently reported inhibitors that target β-catenin/Tcf4 interactions, focusing on the discovery approaches taken in the design of these inhibitors and their bioactivities.
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