Journal ArticleDOI
Ferulic acid and hormesis: Biomedical and environmental implications.
TLDR
In this article, the capacity of ferulic acid to induce hormetic dose responses in biological systems was evaluated. But the authors focused on neuroprotective effects, with particular focus on neuro-protective effect.About:
This article is published in Mechanisms of Ageing and Development.The article was published on 2021-07-15. It has received 23 citations till now. The article focuses on the topics: Ferulic acid.read more
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Optimization of ultrasound extraction of functional compound from makiang seed by response surface methodology and antimicrobial activity of optimized extract with its application in orange juice
TL;DR: In this article , an ultrasound assisted extraction (UAE) was optimized for the extraction of bioactive compound (total phenolic compound and total flavonoid content) with antioxidant activity using response surface methodology based on Box-Behnken design.
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Harnessing Chlorophyll Fluorescence for Phenotyping Analysis of Wild and Cultivated Tomato for High Photochemical Efficiency under Water Deficit for Climate Change Resilience
TL;DR: In this paper, the authors evaluated the responses of wild tomato accession Solanum pennellii LA0716 to moderate drought stress and severe drought stress (SDS), in order to identify the minimum irrigation level for efficient photosynthetic performance, and they concluded that instead of the previously used Fv/Fm ratio, the redox state of quinone A (QA), as it can be estimated by the chlorophyll fluorescence parameter 1 - qL, is a better indicator to evaluate photosynthesis efficiency.
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Hormesis: Transforming disciplines that rely on the dose response
TL;DR: The upregulation of hormetic adaptive mechanisms has the capacity to decelerate the onset and reduce the severity of a broad spectrum of common age-related health, behavioral, and performance decrements and debilitating diseases, thereby significantly enhancing the human health span as mentioned in this paper.
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Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health
TL;DR: An overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research is provided in this paper .
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Hormesis: Wound Healing and Fibroblasts.
TL;DR: Hormetic dose responses are reported commonly in the dermal wound healing process, with the particular focus on cell viability, proliferation, migration and collagen deposition of human and murine fibroblasts with in vitro studies as discussed by the authors .
References
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Journal ArticleDOI
SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
Nathan L. Price,Ana P. Gomes,Alvin J. Y. Ling,Filipe V. Duarte,Alejandro Martin-Montalvo,Brian J. North,Beamon Agarwal,Lan Ye,Giorgio Ramadori,João S. Teodoro,Basil P. Hubbard,Ana T. Varela,James G. Davis,Behzad Varamini,Angela Hafner,Ruin Moaddel,Anabela P. Rolo,Roberto Coppari,Roberto Coppari,Carlos M. Palmeira,Rafael de Cabo,Joseph A. Baur,David A. Sinclair,David A. Sinclair +23 more
TL;DR: Mice treated with a moderate dose of resveratrol showed increased mitochondrial biogenesis and function, AMPK activation, and increased NAD(+) levels in skeletal muscle, whereas SIRT1 knockouts displayed none of these benefits, whereas a mouse overexpressing Sirt1 mimicked these effects.
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Antioxidant properties of ferulic acid and its related compounds.
TL;DR: The results indicated that not only the radical scavenging activity of antioxidants, but also their affinity with lipid substrates, might be important factors in their activity.
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Potential applications of ferulic acid from natural sources.
Naresh Kumar,Vikas Pruthi +1 more
TL;DR: FA exhibits wide variety of biological activities such as antioxidant, antiinflammatory, antimicrobial, antiallergic, hepatoprotective, anticarcinogenic, antithrombotic, increase sperm viability, antiviral and vasodilatory actions, metal chelation, modulation of enzyme activity, activation of transcriptional factors, gene expression and signal transduction.
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Hormesis: why it is important to toxicology and toxicologists.
TL;DR: The article indicates that the hormetic dose response is the most fundamental dose response, significantly outcompeting other leading dose-response models in large-scale, head-to-head evaluations.
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Allelopathy of Aquatic Autotrophs
TL;DR: Field evidence and laboratory studies indicate that allelopathy occurs in all aquatic habitats (marine and freshwater), and that all primary producing organisms (cyanobacteria, micro- and macroalgae as well as angiosperms) are capable of producing and releasing allelopathically active compounds.