Journal ArticleDOI
Fine structure of the A-band in cryo-sections: The structure of the A-band of human skeletal muscle fibres from ultra-thin cryo-sections negatively stained
TLDR
The cryo-sectioning technique has preserved for the first time the axial periodicities in the A-band and that this technique may help to bridge the gap between electron microscopy and X-ray diffraction.About:
This article is published in Journal of Molecular Biology.The article was published on 1977-01-05. It has received 181 citations till now. The article focuses on the topics: Myosin & Striation.read more
Citations
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Journal ArticleDOI
Fiber types in mammalian skeletal muscles.
TL;DR: Mammalian skeletal muscle comprises different fiber types, whose identity is first established during embryonic development by intrinsic myogenic control mechanisms and is later modulated by neural and hormonal factors.
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Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity
TL;DR: The architecture of sequences in the A band region of titin suggests why thick filament structure is conserved among vertebrates and compares two elements that correlate with tissue stiffness that suggest that titin may act as two springs in series.
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Immunochemistry on ultrathin frozen sections
TL;DR: It is considered that cryoultramicrotomy has reached the stage of being useful in studying many questions which will not be easily approached otherwise, and is considered to be useful for immunochemical localization of intracellular antigens.
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Human skeletal muscle fibres: molecular and functional diversity
TL;DR: The present review will describe the mechanisms through which molecular diversity is generated and how fibre types can be identified on the basis of structural and functional characteristics and discuss the advantage that fibre diversity can offer in optimizing muscle contractile performance.
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X-ray diffraction measurements of the extensibility of actin and myosin filaments in contracting muscle.
TL;DR: Observations of filament extensions totaling 2-3 nm per half-sarcomere may necessitate some significant revision of the interpretation of a number of mechanical experiments in muscle, in which it has usually been assumed that virtually all of the elasticity resides in the cross-bridges.
References
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Journal ArticleDOI
The Mechanism of Muscular Contraction
TL;DR: There is now a real possibility of solving the problem in complete detail, provided a way can be found to crystallize a recently purified globular subfragment of the myosin molecule, and some apparently paradoxical properties of the system are revealed.
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Electron microscope studies on the structure of natural and synthetic protein filaments from striated muscle.
TL;DR: The results obtained show that the filaments are structurally polarized, and in muscle are arranged so that all of them attached on one side of a given Z-line point in one direction, whilst those on the other are oppositely oriented.
Journal ArticleDOI
A technique for ultracryotomy of cell suspensions and tissues
TL;DR: The simple technique herein reported allows the ultracryotomy not only of a variety of tissues but also of single cells in suspension, with a preservation and visualization of ultrastructural detail at least equivalent to that obtained with conventional embedding procedures.
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The low-angle X-ray diagram of vertebrate striated muscle and its behaviour during contraction and rigor
Hugh E. Huxley,William Brown +1 more
TL;DR: The results indicate that a co-operative re-organization of the helical arrangement of myosin cross-bridges may occur when they bind to the sites on the actin filaments in such a way as to maximize the number of points of near-registration.
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Qualitative differences between actomyosin ATPase of slow and fast mammalian muscle
Lloyd Guth,Frederick J. Samaha +1 more
TL;DR: It is suggested that there are at least two qualitatively distinct actomyosin ATPases, and the nerve regulates the type of enzyme found in the muscle fiber, and preliminary observations indicate that under the influence of a foreign nerve, some acid-stabile fibers are converted to alkali- stabbed ones.
Related Papers (5)
The low-angle X-ray diagram of vertebrate striated muscle and its behaviour during contraction and rigor
Hugh E. Huxley,William Brown +1 more