Journal ArticleDOI
FlexPen: addressing issues of confidence and convenience in insulin delivery.
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TLDR
Insulin pen devices are discreet and offer patients convenience and flexibility, which may give patients the confidence to overcome issues of needle anxiety and the social embarrassment associated with self-injection and, therefore, may lead to improved adherence to recommended insulin dosing schedules and compliance with multiple- injection regimens.About:
This article is published in Clinical Therapeutics.The article was published on 2005-01-01. It has received 131 citations till now. The article focuses on the topics: Insulin pen & Type 2 diabetes.read more
Citations
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Journal ArticleDOI
Medication adherence and the associated health-economic impact among patients with type 2 diabetes mellitus converting to insulin pen therapy: An analysis of third-party managed care claims data
TL;DR: Among patients with type 2 diabetes treated in a managed care setting, a switch from administration of insulin therapy by vial/syringe to a prefilled insulin analogue pen device was associated with improved medication adherence, fewer claims for hypoglycemic events, reduced emergency department and physician visits, and lower annual treatment costs.
Journal ArticleDOI
Psychological insulin resistance: patient beliefs and implications for diabetes management
TL;DR: Patient psychological insulin resistance is impacted by patients’ beliefs and knowledge about diabetes and insulin, negative self-perceptions and attitudinal barriers, the fear of side effects and complications from insulin use, as well as lifestyle adaptations, restrictions required by insulin Use, and social stigma.
Journal ArticleDOI
Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose.
TL;DR: The hypothesis of insulin absorption as intact liposomes as well as SGC-liposomes showed higher oral bioavailability and the hypoglycemic effect was size-dependent with the highest at 150 nm or 400 nm and was proportionally correlated to the administered dose.
Journal ArticleDOI
3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery
Sophia N. Economidou,Cristiane Patricia Pissinato Pere,Andrew Reid,Md. Jasim Uddin,James F. C. Windmill,Dimitrios A. Lamprou,Dennis Douroumis +6 more
TL;DR: In vivo animal trials revealed fast insulin action with excellent hypoglycaemia control and lower glucose levels achieved within 60 min, combined with steady state plasma glucose over 4 h compared to subcutaneous injections.
Journal ArticleDOI
Novel Microneedle Patches for Active Insulin Delivery are Efficient in Maintaining Glycaemic Control: An Initial Comparison with Subcutaneous Administration
TL;DR: This study presents a novel possibility of insulin delivery that is controllable and requires minimal training and could improve compliance, and thus be beneficial for patients’ glycaemic control.
References
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Journal ArticleDOI
Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
Irene M Stratton,Amanda I Adler,H. Andrew W. Neil,David R. Matthews,Susan E. Manley,Carole A. Cull,D R Hadden,Robert C Turner,Rury R. Holman +8 more
TL;DR: In patients with type 2 diabetes the risk of diabetic complications was strongly associated with previous hyperglycaemia, with the lowest risk being in those with HbA1c values in the normal range (<6.0%).
Journal ArticleDOI
Adherence to long-term therapies: evidence for action.
TL;DR: This report highlights the need for a multi-disciplinary approach to adherence, emphasizes system factors that need to be addressed in successfully implementing adherence-enhancing strategies, and provides illustrative examples of the ways in which professionals have contributed in their own fields of expertise including cardiovascular care among other fields.
Journal ArticleDOI
Adherence to Long-Term Therapies: Evidence for Action:
Sabina De Geest,Eduardo Sabaté +1 more
TL;DR: In this paper, a comprehensive report entitled Adherence to Long-Term Therapies: Evidence for Action w1x was published, focusing on nine chronic conditions and their risk factors.
Journal ArticleDOI
A systematic review of the associations between dose regimens and medication compliance
TL;DR: A review of studies that measured compliance using EM confirmed that the prescribed number of doses per day is inversely related to compliance.
Journal ArticleDOI
A Systematic Review of Adherence With Medications for Diabetes
TL;DR: It is confirmed that many patients for whom diabetes medication was prescribed were poor compliers with treatment, including both OHAs and insulin, however, electronic monitoring systems were useful in improving adherence for individual patients.
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