Journal ArticleDOI
Floating hot-melt extruded tablets for gastroretentive controlled drug release system.
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TLDR
The purpose of this study was to investigate the influence of sodium bicarbonate on the physicochemical properties of controlled release hot-melt extruded (HME) tablets containing Eudragit RS PO and/or EUDragit E PO and the drug release properties and buoyancy in media for HME tablets and directly compressed (DC) tablets were investigated.About:
This article is published in Journal of Controlled Release.The article was published on 2006-10-10. It has received 154 citations till now. The article focuses on the topics: Controlled release & Dosage form.read more
Citations
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Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TL;DR: The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.
Journal ArticleDOI
Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation
TL;DR: This review discussed the importance of using the quality by design approach in drug development, evaluated the process analytical technology used in pharmaceutical HME monitoring and control, discussed techniques used in HME, and emphasized the potential for monitoring and controlling hot-melt technology.
Floating Drug Delivery System-A Review
TL;DR: Floating Drug delivery system are designed to prolong the gastric residence time after oral administration, at particular site and controlling the release of drug especially useful for achieving controlled plasma level a swell as improving bioavailability.
Journal ArticleDOI
Applications of hot-melt extrusion for drug delivery.
TL;DR: The range of HME applications for pharmaceutical dosage forms, such as tablets, capsules, films and implants for drug delivery through oral, transdermal, transmucosal, transungual, as well as other routes of administration are reviewed.
Journal ArticleDOI
Melt extrusion with poorly soluble drugs – An integrated review
Michael A. Repka,Suresh Bandari,Venkata Raman Kallakunta,Anh Q. Vo,Haley McFall,Manjeet B. Pimparade,Ajinkya M. Bhagurkar +6 more
TL;DR: This review is focused on the recent reports on the solubility enhancement via HME and provides an update for the manufacturing/scaling up aspects of melt extrusion and analyzes the strengths, weaknesses, opportunities and threats of HME application in the pharmaceutical industry.
References
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Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Upper Gastrointestinal pH in Seventy-Nine Healthy, Elderly, North American Men and Women
Tanya L. Russell,Rosemary R. Berardi,Jeffrey L. Barnett,Lambros C. Dermentzoglou,Kathleen M. Jarvenpaa,Stephen Schmaltz,Jennifer B. Dressman +6 more
TL;DR: Although fasted gastric pH, fasted duodenal pH, and duodanal pH during the meal differ statistically from those observed in young subjects, the differences are not expected to be clinically significant in terms of drug absorption for the majority of elderly subjects.
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Hollow Microspheres for Use as a Floating Controlled Drug Delivery System in the Stomach
TL;DR: In this article, hollow microspheres (microballoons), loaded with drug in their outer polymer shells, were prepared by a novel emulsion-solvent diffusion method, and the drugs incorporated in the solidified shell of the polymer were found to be partially or completely amorphous.
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Characterization of urease from Campylobacter pylori.
TL;DR: The Urease of C. pylori appears to be biochemically unique from the enzymes of other common urease-producing species.
Journal ArticleDOI
Floating matrix tablets based on low density foam powder: effects of formulation and processing parameters on drug release.
TL;DR: The floating behavior of the low density drug delivery systems could be combined with accurate control of the drug release patterns and could effectively be modified by varying the "matrix-forming polymer/foam powder" ratio.