Journal ArticleDOI
Formation of a dihydropyridine derivative as a potential cross-link derived from malondialdehyde in physiological systems
TLDR
Initial model studies show that malondialdehyde reacts with lysine to form a dihydropyridine derivative rather than the unstable imidopropene Schiff base previously reported, and could react further to cross‐link collagen and stiffen the aorta, thereby promoting further glycation.About:
This article is published in FEBS Letters.The article was published on 1998-01-16. It has received 93 citations till now. The article focuses on the topics: Dihydropyridine & Glycation.read more
Citations
More filters
Journal ArticleDOI
Mechanisms of maturation and ageing of collagen
TL;DR: An understanding of these mechanisms is now leading to the development of inhibitors of glycation and compounds capable of cleaving the cross-links, thus alleviating the devastating effects of ageing.
Journal ArticleDOI
Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): An overview of their mechanisms of formation
TL;DR: The aim of the present review is to group the main AGEs and ALEs and to describe, for each of them, the precursors and mechanisms of formation.
Journal ArticleDOI
Role of reactive aldehyde in cardiovascular diseases.
TL;DR: The protein-bound aldehydes can be detected as constituents not only in in vitro oxidized low-density lipoproteins but also in animal models of atherosclerosis and in human patients with increased risk factors or clinical manifestations of Atherosclerosis, indicating that they could indeed be involved in the caldiovascular pathology.
Journal ArticleDOI
Protein adducts generated from products of lipid oxidation: focus on HNE and one.
TL;DR: Model studies are revealing the structure of adducts that can be more readily identified in mass spectrometric studies on proteins exposed to the various pure aldehydes or to peroxidized PUFAs.
References
More filters
Journal ArticleDOI
The role of lipid peroxidation and antioxidants in oxidative modification of LDL.
TL;DR: A comprehensive survey on the compositional properties of LDL relevant for its susceptibility to oxidation, on the mechanism and kinetics of LDL oxidation, and on the chemical and physico-chemical properties of HDL oxidized by exposure to copper ions is provided.
Journal ArticleDOI
Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids
K. S. Chio,Aloys L. Tappel +1 more
Journal ArticleDOI
Quantification of malondialdehyde and 4-hydroxynonenal adducts to lysine residues in native and oxidized human low-density lipoprotein
Jesús R. Requena,Min Xin Fu,Mahtab U. Ahmed,Alicia J. Jenkins,Timothy J. Lyons,John W. Baynes,Suzanne R. Thorpe +6 more
TL;DR: LM, LML and LHNE should be useful as biomarkers of lipid peroxidative modification of protein and of oxidative stress in vitro and in vivo and are the first report of direct chemical measurement of MDA and HNE adducts to lysine residues in LDL.
Journal ArticleDOI
The role of glycation cross-links in diabetic vascular stiffening
TL;DR: It is proposed that this increased stiffness can be attributed to glycation-induced inter-molecular cross- links based on a direct analysis of the two known glycation cross-links, the fluorescent pentosidine and the non-fluorescent NFC-1.
Journal ArticleDOI
Assay of Malondialdehyde in Biological Fluids by Gas Chromatography-Mass Spectrometry
TL;DR: This assay provides two forms of confirmation of the analyte, retention time and mass ion, thus minimizing error due to interfering compounds, and has successfully applied to biological samples including plasma, tissue homogenates, and sperm.