Journal ArticleDOI
Formation of N-nitroso compounds: chemistry, kinetics, and in vivo occurrence.
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This article is published in Toxicology and Applied Pharmacology.The article was published on 1975-03-01. It has received 723 citations till now. The article focuses on the topics: Nitroso Compounds.read more
Citations
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Journal ArticleDOI
Biochemistry of nitric oxide and its redox-activated forms
TL;DR: The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.
Journal ArticleDOI
Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species.
TL;DR: Critical issues regarding this biological process, namely the biochemical pathways for nitration of tyrosine residues in vivo, potential protein targets, and pathophysiological consequences of protein tyrosines nitration are addressed.
Journal ArticleDOI
Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC.
TL;DR: Evidence that specific cancers are caused by NOC and clues from mutations in ras and p53 genes in human tumors about whether NOC are etiologic agents are discussed and some general conclusions are drawn.
Journal ArticleDOI
N-Nitrosodimethylamine (NDMA) as a Drinking Water Contaminant: A Review
William A. Mitch,Jonathan O. Sharp,R. Rhodes Trussell,Richard L. Valentine,Lisa Alvarez-Cohen,David L. Sedlak +5 more
TL;DR: In this article, ultraviolet (UV) treatment can effectively remove NDMA, there is considerable interest in the development of less expensive alternative treatment technologies, such as approaches for removing organic nitrogen-containing NDMA precursors prior to chlorination and the use of sunlight photolysis.
References
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Journal ArticleDOI
[Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].
Book ChapterDOI
Carcinogenic Nitroso Compounds
P N Magee,J M Barnes +1 more
TL;DR: The variation in the response of different organs to the carcinogenic nitroso compounds is of interest in relation to the biochemical changes that may be essential for the initiation of a carcinogenic change.
Journal ArticleDOI
Nitrosamines as environmental carcinogens.
TL;DR: Human cancer might be caused by nitrosamines formed in the body from ingested nitrites and secondary amines, and cooking could be a source ofsecondary amines.
Journal ArticleDOI
Ascorbate-Nitrite Reaction: Possible Means of Blocking the Formation of Carcinogenic N-Nitroso Compounds
TL;DR: The formation of carcinogenic N-nitroso compounds by the chemical reaction between nitrous acid and oxytetracycline, morpholine, piperazine, N-methylaniline, methylurea, and (in some experiments) dimethylamine was blocked by ascorbic acid.
Journal ArticleDOI
Nitrates, Nitrites, and Nitrosamines
I. A. Wolff,A. E. Wasserman +1 more
TL;DR: The status of knowledge of nitrosamines is reviewed to gain perspective and to distinguish between actual and potential occurrence of these compounds or their formation in vivo (or both).