Journal ArticleDOI
Functionalized Nanodiamonds as Nanoagents in Materials and Life Sciences
Inga Hannstein,Msaukiranji Mkandawire,Gerhard Rödel,Jörg Opitz,Viktoria Alexejewna Lapina,Jürgen Schreiber +5 more
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TLDR
In this paper, the potential of ultradisperse nanodiamonds for nanoagents in materials and life sciences by chemical or biological activation is shown, which can be implemented as nanoagents.Abstract:
Ultradisperse nanodiamonds can be implemented as nanoagents in materials and life sciences by chemical or biological activation. In this paper we show the potential of nanodiamonds for spe...read more
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Detonation nanodiamonds biofunctionalization and immobilization to titanium alloy surfaces as first steps towards medical application.
Juliana Pereira Lopes Gonçalves,Afnan Q Shaikh,Afnan Q Shaikh,Manuela Reitzig,Daria A. Kovalenko,Daria A. Kovalenko,Jan Michael,Jan Michael,Rene Beutner,Gianaurelio Cuniberti,Dieter Scharnweber,Jörg Opitz,Jörg Opitz +12 more
TL;DR: This work presents the recent results on chemical modification of the nanodiamond surface with phosphate groups and their electrochemically assisted immobilization on titanium-based materials to increase adhesion at biomaterial surfaces.
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Electrodeposition of pristine and composite poly(3,4-ethylenedioxythiophene) layers studied by electro-acoustic impedance measurements
TL;DR: In this paper, a mean field model was used to interpret the electroacoustic impedance of piezoelectric quartz crystals with gold electrodes as a microbalance, which yields the complex shear modulus of the composite layers.
Patent
A method for producing zeta negative nanodiamond dispersion and zeta negative nanodiamond dispersion
Vesa Myllymäki,Jesse Syrén +1 more
TL;DR: In this article, a method for producing zeta negative single digit carboxylated nanodiamond dispersion was proposed, which adjusted pH of the ZN suspension to at least 7, and subjecting the pH adjusted suspension to beads milling.
Journal ArticleDOI
Targeting Diamond Nanoparticles into Folate-Receptor Expressing HeLa Cells
TL;DR: It is suggested that is it possible to use the conjugate as a targeted nanoplatform for targeted delivery of diagnostic and therapeutic agents to tumor cells.
References
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Journal ArticleDOI
Bright Fluorescent Nanodiamonds: No Photobleaching and Low Cytotoxicity
TL;DR: The fluorescent nanodiamonds (FND) show no sign of photobleaching and can be taken up by mammalian cells with minimal cytotoxicity and the nanomaterial can have far-reaching biological applications.
Journal ArticleDOI
Characterization and application of single fluorescent nanodiamonds as cellular biomarkers
Chi-Cheng Fu,Hsu-Yang Lee,Kowa Chen,Tsong-Shin Lim,Hsiao-Yun Wu,Po-Keng Lin,Pei-Kuen Wei,Pei-Hsi Tsao,Huan-Cheng Chang,Wunshain Fann,Wunshain Fann +10 more
TL;DR: In this article, the authors presented the results of characterization and application of single fluorescent nanodiamonds as cellular biomarkers, and showed that under the same excitation conditions, the fluorescence of a single 35-nm diamond is significantly brighter than that of a simple dye molecule such as Alexa Fluor 546, which was photobleached in the range of 10 s at a laser power density of 104 W/cm2.
Characterization and applications of single fluorescent nanodiamonds as cellular biomarkers
Chi-Cheng Fu,Hsu-Yang Lee,Kowa Chen,Tsong-Shin Lim,Hsiao-Yun Wu,Po-Keng Lin,Pei-Kuen Wei,Pei-Hsi Tsao,Huan-Cheng Chang,Wunshain Fann +9 more
TL;DR: The feasibility of using surface-functionalized fluorescent nanodiamonds as single-particle biomarkers is demonstrated with both fixed and live HeLa cells, and the fluorescence of a single 35-nm diamond is significantly brighter than that of asingle dye molecule such as Alexa Fluor 546.
Journal ArticleDOI
Are diamond nanoparticles cytotoxic
Amanda M. Schrand,Houjin Huang,Cataleya Carlson,John J. Schlager,Eiji Ōsawa,Saber M. Hussain, ,‡ and,Liming Dai +6 more
TL;DR: Assays of cell viability such as mitochondrial function (MTT) and luminescent ATP production showed that nanodiamonds were not toxic to a variety of cell types, and results suggest that nandiamonds could be ideal for many biological applications in a diverse range ofcell types.
Journal ArticleDOI
Active Nanodiamond Hydrogels for Chemotherapeutic Delivery
TL;DR: Doxorubicin hydrochloride (DOX), an apoptosis-inducing drug widely used in chemotherapy, was successfully applied toward the functionalization of nanodiamond materials (NDs) and introduced toward murine macrophages as well as human colorectal carcinoma cells with preserved efficacy.