Journal ArticleDOI
GABA release in the dorsal raphe nucleus: role in the control of REM sleep.
Douglas A. Nitz,Jerome M. Siegel +1 more
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TLDR
It is found that REM sleep is accompanied by a selective increase in GABA release, but not by a change in glutamate or glycine release in the dorsal raphe nucleus, which implicate GABA release as a critical element in the production of the REM sleep state.Abstract:
The cessation of firing of serotonergic dorsal raphe neurons is a key controlling event of rapid eye movement (REM) sleep. We tested the hypothesis that this cessation of activity is due to gamma-aminobutyric acid (GABA) release using the in vivo microdialysis technique. We found that REM sleep is accompanied by a selective increase in GABA release, but not by a change in glutamate or glycine release in the dorsal raphe nucleus. Microinjection of the GABA agonist muscimol into the dorsal raphe increased REM sleep, although microperfusion of the GABA antagonist picrotoxin blocked REM sleep. These results implicate GABA release as a critical element in the production of the REM sleep state and in the control of discharge in serotonergic neurons across the sleep/wake cycle.read more
Citations
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Control of Sleep and Wakefulness
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The neurobiology of sleep: genetics, cellular physiology and subcortical networks.
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The human raphe nuclei and the serotonergic system
TL;DR: Recent experimental data support the role of serotonin in modulating brain development, such that a dysfunction in serotonergic transmission during early life could lead to long lasting structural and functional alterations.
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Neurobiological Mechanisms Involved in Sleep Bruxism
TL;DR: The final section of this review proposes that RMMA during sleep has a role in lubricating the upper alimentary tract and increasing airway patency.
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The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.
TL;DR: This article reviews the research that led to the isolation of the hypocretin/orexin peptides, their receptors and the activity of these molecules as the authors currently understand them and proposed model in which the cells that make these peptides might be involved in arousal state control.
References
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Journal ArticleDOI
An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat
Efrain C. Azmitia,Menahem Segal +1 more
TL;DR: The differential projections from the dorsal raphe and median raphe nuclei of the midbrain were autoradiographically traced in the rat brain after 3H‐proline micro‐injections to identify six ascending fiber tracts.
Journal ArticleDOI
Dorsal raphe neurons: depression of firing during sleep in cats.
Dennis McGinty,Ronald M. Harper +1 more
TL;DR: The results of lesion and pharmacological experiments suggest that 5-HT-containing neurons localized in the raphe nuclei of the brain stem participate functionally in the control of slow wave sleep (SWS) 24-27 as well as in a variety of waking behavioral processes s,l°.
Journal Article
A re-evaluation of the effects of lesions of the pontine tegmentum and locus coeruleus on phenomena of paradoxical sleep in the cat.
TL;DR: The conclusion drawn from these experiments and from a review of the literature is that the hypotheses stating that the locus coeruleus or other isolated nuclei of the pons are specifically concerned with the initiation of paradoxical sleep are not clearly supported by available evidence.
Journal ArticleDOI
Afferent projections to the cholinergic pedunculopontine tegmental nucleus and adjacent midbrain extrapyramidal area in the albino rat. I. Retrograde tracing studies.
TL;DR: The afferent connections of the pedunculopontine tegmental nucleus (PPT) and the adjacent midbrain extrapyramidal area (MEA) were examined by retrograde tracing with wheat germ agglutinin‐conjugated horseradish peroxidase (WGA‐HRP).
Journal ArticleDOI
Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity
TL;DR: Electrophysiological evidence for decreased postsynaptic sensitivity to GABA following chronic benzodiazepine administration is presented as measured by the direct iontophoretic application of GABA and serotonin onto serotonergic cells in the midbrain dorsal raphe nucleus (DRN), known to receive GABAergic input.
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Dorsal raphe neurons: depression of firing during sleep in cats.
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