Journal ArticleDOI
Galanin: Evidence for a hypothalamic site of action to release growth hormone
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TLDR
The failure of galanin to alter GH release from dispersed, cultured anterior pituitary cells in vitro further suggests that endogenous Galanin plays a neuromodulatory role at the level of the median eminence, possibly affecting the release of known GH-releasing and/or inhibiting factors.About:
This article is published in Peptides.The article was published on 1986-01-01. It has received 205 citations till now. The article focuses on the topics: Galanin & Anterior pituitary.read more
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Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human
TL;DR: The pathophysiology of the GHRH somatostatin-GH-IGF-I feedback axis is reviewed and it is proposed that this system is best viewed as a multivalent feedback network that is exquisitely sensitive to an array of neuroregulators and environmental stressors and genetic restraints.
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Neuroendocrine Control of Growth Hormone Secretion
TL;DR: The secretion of growth hormone is regulated through a complex neuroendocrine control system, especially by the functional interplay of two hypothalamic hypophysiotropic hormones, GH-releasing hormone (GHRH) and somatostatin (SS), exerting stimulatory and inhibitory influences, respectively, on the somatotrope.
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Anatomy and physiology of central galanin-containing pathways
TL;DR: C O N T E N T S Abbreviations (C O n T E n T S) are used in this paper for abbreviations of nouns and adjectives.
Journal ArticleDOI
Neuroendocrine control of growth hormone secretion.
TL;DR: Better understanding of the function of GHRH, SS, and their receptors and, hence, of neural regulation of GH secretion in health and disease has been achieved with the discovery of a new class of fairly specific, orally active, small peptides and their congeners, the GH-releasing peptides, acting on specific, ubiquitous seven-transmembrane domain receptors, whose natural ligands are not yet known.
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Isolation and characterization of a complementary DNA (galanin) clone from estrogen-induced pituitary tumor messenger RNA.
TL;DR: Results provide the first evidence of a physiological regulator (estrogen) of the expression of the galanin gene and imply that Galanin is secreted by prolactin-secreting tumors.
References
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Galanin — a novel biologically active peptide from porcine intestine
TL;DR: It was found that galanin consists of 29 amino acids and the complete amino acid sequence is: contract smooth muscle preparations from the rat and to cause a mild and sustained hyperglycemia in dog.
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A galanin-like peptide in the central nervous system and intestine of the rat.
Åke Rökaeus,T. Melander,Tomas Hökfelt,Jan M. Lundberg,Kazuhiko Tatemoto,Mats Carlquist,V. Mutt +6 more
TL;DR: It is reported that GAL-like immunoreactivity occurs in wide-spread systems in the rat CNS and intestine.
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Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats
TL;DR: Results indicate that NPY acts on structures adjacent to the third ventricle to inhibit the secretion of LH and growth hormone but not follicle-stimulating hormone, whereas it can directly stimulate all three hormones from the cells of the anterior pituitary in vitro.
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Vasoactive Intestinal Peptide: Evidence for a Hypothalamic Site of Action to Release Growth Hormone, Luteinizing Hormone, and Prolactin in Conscious Ovariectomized Rats*
TL;DR: Ovariectomized conscious rats bearing chronically implanted third ventricular cannula were injected with varying doses of vasoactive intestinal peptide, and plasma LH, PRL, GH, TSH, and FSH levels were measured by RIA in jugular blood samples drawn through an indwelling silastic cannula.
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In vivo and in vitro effects of cholecystokinin on gonadotropin, prolactin, growth hormone and thyrotropin release in the rat.
TL;DR: The results indicate that CCK can alter pituitary hormone release via a hypothalamic action and suggest that it may act as t transmitter or modulator of neuronal activity controlling the release of hypothalamic releasing and/or inhibiting hormones.