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Gamma-aminobutyric acid neuropharmacological investigations on narcosis produced by nitrogen, argon, or nitrous oxide.

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TLDR
The results support a selective antagonism by gabazine and flumazenil of the narcotic action of nitrogen and argon.
Abstract
Inhaled anesthetics, including the gaseous anesthetics nitrous oxide and xenon, are thought to act by interacting directly with ion-channel receptors. In contrast, little is known about the mechanism of action of inert gases that show only narcotic potency at high pressures, such as nitrogen or argo

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Citations
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Journal ArticleDOI

Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury

TL;DR: Argon showed a neuroprotective effect in both in vitro models of oxygen-glucose deprivation and traumatic brain injury, and this results justify further in vivo animal research.
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The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats

TL;DR: These studies indicate that argon and xenon provide neuroprotection against both moderate and severe hypoxia–ischemic brain injury likely through prosurvival proteins synthesis.
Journal ArticleDOI

Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury

TL;DR: The data suggest that the cheap and widely available noble gas argon may have potential as a neuroprotectant for the future.
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Neuroprotective effects of argon in an in vivo model of transient middle cerebral artery occlusion in rats

TL;DR: In this paper, the authors analyzed the possible neuroprotective role of argon in an in vivo rat model of acute focal cerebral ischemia using the endoluminal thread model.
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Protein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies and implications for the mechanism of inhaled anesthetic action

TL;DR: It is proposed that alterations of cytosolic globular protein functions by general anesthetics would be responsible for the early stages of anesthesia such as amnesia and hypnosis and that additional alterations of ion-channel membrane receptor functions are required for deeper effects that progress to "surgical" anesthesia.
References
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The Rat Brain in Stereotaxic Coordinates

TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Molecular and cellular mechanisms of general anaesthesia

TL;DR: It is now clear that anaesthetics act directly on proteins rather than on lipids, with potentiation of postsynaptic inhibitory channel activity best fitting the pharmacological profile observed in general anaesthesia.
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Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin

TL;DR: It is shown that N2O, at anesthetically-relevant concentrations, inhibits both ionic currents and excitotoxic neurodegeneration mediated through NMDA receptors and, like other NMDA antagonists, produces neurotoxic side effects which can be prevented by drugs that enhance CABAergic inhibition.
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How does xenon produce anaesthesia

TL;DR: Although most general anaesthetics enhance the activity of inhibitory GABAA (γ-aminobutyric acid type-A) receptors, it is found that the effects of xenon on these receptors are negligible and xenon potently inhibits the excitatory NMDA (N-methyl-D-aspartate) receptor channels, which may account for many of Xenon's attractive pharmacological properties.
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