Journal ArticleDOI
Gamma-aminobutyric acid neuropharmacological investigations on narcosis produced by nitrogen, argon, or nitrous oxide.
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The results support a selective antagonism by gabazine and flumazenil of the narcotic action of nitrogen and argon.Abstract:
Inhaled anesthetics, including the gaseous anesthetics nitrous oxide and xenon, are thought to act by interacting directly with ion-channel receptors. In contrast, little is known about the mechanism of action of inert gases that show only narcotic potency at high pressures, such as nitrogen or argoread more
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Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury
Philip D Loetscher,Jan Rossaint,Rolf Rossaint,Joachim Weis,Michael Fries,Astrid V. Fahlenkamp,Yu-Mi Ryang,Oliver Grottke,Mark Coburn +8 more
TL;DR: Argon showed a neuroprotective effect in both in vitro models of oxygen-glucose deprivation and traumatic brain injury, and this results justify further in vivo animal research.
Journal ArticleDOI
The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats
Lei Zhuang,Ting Yang,Hailin Zhao,Antonio Rei Fidalgo,Marcela P. Vizcaychipi,Robert D. Sanders,Buwei Yu,Masao Takata,Mark R. Johnson,Daqing Ma +9 more
TL;DR: These studies indicate that argon and xenon provide neuroprotection against both moderate and severe hypoxia–ischemic brain injury likely through prosurvival proteins synthesis.
Journal ArticleDOI
Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury
Noorulhuda Jawad,Maleeha Rizvi,Jianteng Gu,Jianteng Gu,Olar Adeyi,Guocai Tao,Mervyn Maze,Daqing Ma +7 more
TL;DR: The data suggest that the cheap and widely available noble gas argon may have potential as a neuroprotectant for the future.
Journal ArticleDOI
Neuroprotective effects of argon in an in vivo model of transient middle cerebral artery occlusion in rats
Yu-Mi Ryang,Astrid V. Fahlenkamp,Rolf Rossaint,Dominik Wesp,Philip D Loetscher,Cordian Beyer,Mark Coburn +6 more
TL;DR: In this paper, the authors analyzed the possible neuroprotective role of argon in an in vivo rat model of acute focal cerebral ischemia using the endoluminal thread model.
Journal ArticleDOI
Protein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies and implications for the mechanism of inhaled anesthetic action
Nathalie Colloc'h,Jana Sopkova-de Oliveira Santos,Pascal Retailleau,Denis Vivarès,Françoise Bonneté,Béatrice Langlois d’Estainto,Bernard Gallois,Alain Brisson,Jean-Jacques Risso,Marc Lemaire,Thierry Prangé,Jacques H. Abraini +11 more
TL;DR: It is proposed that alterations of cytosolic globular protein functions by general anesthetics would be responsible for the early stages of anesthesia such as amnesia and hypnosis and that additional alterations of ion-channel membrane receptor functions are required for deeper effects that progress to "surgical" anesthesia.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Molecular and cellular mechanisms of general anaesthesia
TL;DR: It is now clear that anaesthetics act directly on proteins rather than on lipids, with potentiation of postsynaptic inhibitory channel activity best fitting the pharmacological profile observed in general anaesthesia.
Journal ArticleDOI
Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.
S. John Mihic,S. John Mihic,Qing Ye,Marilee J. Wick,Marilee J. Wick,Vladimir V. Koltchine,Matthew D. Krasowski,Suzanne E. Finn,Maria Paola Mascia,C. Fernando Valenzuela,Kirsten K. Hanson,Eric P. Greenblatt,R. Adron Harris,R. Adron Harris,Neil L. Harrison +14 more
TL;DR: Observations support the idea that anaesthetics exert a specific effect on these ion-channel proteins, and allow for the future testing of specific hypotheses of the action of anaesthetic action.
Journal ArticleDOI
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin
Vesna Jevtovic-Todorovic,Slobodan M. Todorovic,Steven Mennerick,S Powell,Krikor Dikranian,N. Benshoff,Charles F. Zorumski,John W. Olney +7 more
TL;DR: It is shown that N2O, at anesthetically-relevant concentrations, inhibits both ionic currents and excitotoxic neurodegeneration mediated through NMDA receptors and, like other NMDA antagonists, produces neurotoxic side effects which can be prevented by drugs that enhance CABAergic inhibition.
Journal ArticleDOI
How does xenon produce anaesthesia
TL;DR: Although most general anaesthetics enhance the activity of inhibitory GABAA (γ-aminobutyric acid type-A) receptors, it is found that the effects of xenon on these receptors are negligible and xenon potently inhibits the excitatory NMDA (N-methyl-D-aspartate) receptor channels, which may account for many of Xenon's attractive pharmacological properties.