Journal ArticleDOI
Gamma-globulins: quantitative relationships in human serum and nonvascular fluids.
W. B. Chodirker,T. B. Tomasi +1 more
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TLDR
Though ylA-globulin is present in only small amounts in serum, it represents a major fraction of the gamma globulin of tears, bile, saliva, colostrum, and fluid of the small intestine.Abstract:
Three types of gamma-globulins, gamma(2), gamma(IA), and yim, are present in certain body fluids and secretions in proportions significantly different from those of normal human serum. A lthough ylA-globulin is present in only small amounts in serum, it represents a major fraction of the gamma globulin of tears, bile, saliva, colostrum, and fluid of the small intestine.read more
Citations
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Characteristics of an immune system common to certain external secretions
TL;DR: The γ1A present in saliva and colostrum exists largely in the form of higher polymers, the major component of which has a sedimentation coefficient of 11S, and its properties including the local production of a distinctive type of antibody separate it from the "systemic" system responsible for the production of circulating antibody.
Journal ArticleDOI
The immune geography of IgA induction and function
TL;DR: The mechanisms underlying selective IgA induction of mucosal B cells for IgA production and the immune geography of their homing characteristics are discussed, and the functionality of secretory IgA directed against both commensal organisms and pathogens is reviewed.
Journal ArticleDOI
Mucosal immunity: induction, dissemination, and effector functions.
TL;DR: Mucosal vaccines would make immunization procedures easier, be better suited for mass administration, and most efficiently induce immune exclusion – a term coined for non‐inflammatory antibody shielding of internal body surfaces – mediated principally by secretory immunoglobulin A (SIgA).
Journal ArticleDOI
Receptor-mediated Immunoglobulin G Transport Across Mucosal Barriers in Adult Life: Functional Expression of FcRn in the Mammalian Lung
Gerburg M. Spiekermann,Patricia W. Finn,Patricia W. Finn,E. Sally Ward,Jennifer A. Dumont,Bonny L. Dickinson,Bonny L. Dickinson,Richard S. Blumberg,Richard S. Blumberg,Wayne I. Lencer,Wayne I. Lencer +10 more
TL;DR: Test the idea that the MHC class I–related Fc-receptor, FcRn, transports IgG across the mucosal surface of the human and mouse lung from lumen to serosa and shows that mucosal surfaces that express F cRn reabsorb IgG and explain a mechanism by which IgG may act in immune surveillance to retrieve lumenal antigens for processing in the lamina propria or systemically.
References
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Journal ArticleDOI
THE SELECTIVE OCCURRENCE OF γ1A GLOBULINS IN CERTAIN BODY FLUIDS
T. B. Tomasi,S. Zigelbaum +1 more
Journal ArticleDOI
Beta-2A-Globulin as a possible carrier of allergic reaginic activity.
J. F. Heremans,J.-P. Vaerman +1 more
TL;DR: Positive evidence has never been brought forward that β2A-globulin might be the essential carrier of reaginic activity, but this may be due to the fact that all skin-sensitizing preparations so far obtained contained appreciable amounts of γ- globulin.
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The relative transmission of the fractions of papain hydrolyzed homologous gamma-globulin from the uterine cavity to the foetal circulation in the rabbit.
TL;DR: It is suggested that fraction III, which contains most of the antigenic groups of the original molecules, also has the configuration recognized by the cells as homologous γ-globulin.
Journal ArticleDOI
The Structure, Function and Significance of the Immune Globulins*
TL;DR: While they resemble each other in many ways, it is apparent that each has a sufficient number of unique characteristics to permit their separation into three distinct groups, and all of them have a broad electrophoretic distribution in the range of the yor slow P-globulin fraction.