The immune geography of IgA induction and function
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TLDR
The mechanisms underlying selective IgA induction of mucosal B cells for IgA production and the immune geography of their homing characteristics are discussed, and the functionality of secretory IgA directed against both commensal organisms and pathogens is reviewed.About:
This article is published in Mucosal Immunology.The article was published on 2008-01-01 and is currently open access. It has received 901 citations till now. The article focuses on the topics: Immunoglobulin A & Mucosal immunology.read more
Citations
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Regulation of Adaptive Immunity by the Innate Immune System
TL;DR: Questions are discussed including the mechanisms by which pathogen-specific innate immune recognition activates antigen-specific adaptive immune responses and the roles of different types of innate immune Recognition in host defense from infection and injury.
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Intestinal permeability – a new target for disease prevention and therapy
Stephan C. Bischoff,Giovanni Barbara,Wim A. Buurman,Theo Ockhuizen,Jörg-Dieter Schulzke,Matteo Serino,Herbert Tilg,Alastair J.M. Watson,Jerry M. Wells +8 more
TL;DR: Intestinal permeability, which is a feature of intestinal barrier function, is increasingly recognized as being of relevance for health and disease, and therefore, this topic warrants more attention.
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Mucin dynamics and enteric pathogens
TL;DR: The components of the secreted and cell surface mucosal barriers and the evidence that they form an effective barricade against potential pathogens are described and dynamic alterations in the mucin barrier are described driven by host innate and adaptive immune responses to infection.
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Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
TL;DR: Dysregulated TLR signalling by intestinal epithelial cells may explain how colonic bacteria and inflammation promote colorectal cancer.
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The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions
TL;DR: The colon mucus is organized in two layers: an inner, stratified mucus layer that is firmly adherent to the epithelial cells and approximately 50 μm thick; and an outer, nonattached layer, usually approximately 100 μm thickness as measured in mouse.
References
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Prokaryotes: The unseen majority
TL;DR: The number of prokaryotes and the total amount of their cellular carbon on earth are estimated to be 4-6 x 10(30) cells and 350-550 Pg of C (1 Pg = 10(15) g), respectively, which is 60-100% of the estimated total carbon in plants.
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Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
Masamichi Muramatsu,Kazuo Kinoshita,Sidonia Fagarasan,Shuichi Yamada,Yoichi Shinkai,Tasuku Honjo +5 more
TL;DR: Results suggest that AID may be involved in regulation or catalysis of the DNA modification step of both class switching and somatic hypermutation in CH12F3-2 B lymphoma.
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Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria
Andrew J. Macpherson,Therese Uhr +1 more
TL;DR: It is shown that, even though commensal bacteria are rapidly killed by macrophages, intestinal dendritic cells (DCs) can retain small numbers of live commensals for several days, which allows DCs to selectively induce IgA, which helps protect against mucosal penetration by Commensals.
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DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
Mikhail B. Litinskiy,Bernardetta Nardelli,David M. Hilbert,Bing He,András Schaffer,Paolo Casali,Andrea Cerutti +6 more
TL;DR: By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses.
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The Route of Re-Circulation of Lymphocytes in the Rat
J. L. Gowans,E. J. Knight +1 more
TL;DR: It was concluded that the re-circulating pool of small lymphocytes was located in the lymphoid tissue, the thymus excepted, and that the rapid ‘homing’ of cells into the lymph nodes had its basis in the special affinity ofsmall lymphocytes for the endothelium of the post-capillary venules.