Journal ArticleDOI
Gangliosides GM1 and GD1b are antigens for IgM M-protein in a patient with motor neuron disease.
Lorenza Freddo,Robert K. Yu,Norman Latov,Peter D. Donofrio,Arthur P. Hays,Harry S. Greenberg,James W. Albers,A G Allessi,D. Keren +8 more
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TLDR
A patient with an IgM M-protein and lower motor neuron disease was studied to identify the antigens to which the M- protein bound, indicating reactivity to the galactosyl(beta 1-3)N-acetylgalactosaminyl moiety shared by GM1, GD1b, and asialo-GM1.Abstract:
We studied a patient with an IgM M-protein and lower motor neuron disease to identify the antigens to which the M-protein bound. Gangliosides from peripheral nerve and spinal cord were separated by high-performance thin-layer chromatography and immunostained with the patient's serum. The serum IgM immunostained two gangliosides identified as GM1 and GD1b, and immunostaining was specific for the M-protein light chain type. IgM-binding to the two gangliosides was detectable by ELISA at serum dilutions of greater than 1:10,000, and the M-protein was selectively immunoabsorbed by liposomes containing GM1 or GD1b. The IgM M-protein also bound to asialo-GM1, indicating reactivity to the galactosyl(beta 1-3)N-acetylgalactosaminyl moiety shared by GM1, GD1b, and asialo-GM1.read more
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Global Epidemiology of Campylobacter Infection
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Peripheral neuropathies and anti-glycolipid antibodies.
Hugh J. Willison,Nobuhiro Yuki +1 more
TL;DR: This review charts the progress of anti-glycolipid antibodies in neuropathy, from their original discovery 20 years ago in immunoglobulin M paraproteinaemic neuropathy through to current discoveries mapping their relationship to subtypes of Guillain-Barré syndrome.
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Serum anti‐GQ1b IgG antibody is associated with ophthalmoplegia in Miller Fisher syndrome and Guillain‐Barré syndrome: Clinical and immunohistochemical studies
TL;DR: It is concluded that serum IgG antibody against GQ1b is very closely associated with acute postinfectious ophthalmoplegia in MFS and GBS and with other neurologic or non-neurologic disorders.
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A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside.
Alan Pestronk,David R. Cornblath,Amjad A. Ilyas,H. Baba,Richard H. Quarles,John W. Griffin,K. Alderson,Robert N. Adams +7 more
TL;DR: 2 patients with a treatable, immune‐mediated motor polyneuropathy associated with antibodies to defined neural antigens, initially diagnosed as having lower motor neuron forms of amyotrophic lateral sclerosis are reported.
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